Integrated Project - ADN and genomes
The DNA sequences of data are increasingly abundant. Sequencing is a routine in many research areas (biology, health, agriculture and agronomy, food sciences, environment), with ever lower costs and growing applications (clinical data for diseases, crop improvement of agronomic interest, food security, balance and preservation of biodiversity ...). From these data are now emerging new scientific fields to be used in the socio-economic sphere, in the hospital, for instance, where such dedicated services work daily. The community NUMEV has developed since many years advanced methods to analyze genomic data and make sense of them in the context of innovative applications.
On similar grounds, thanks to the great advances in microscopy and spectroscopy techniques, understanding how genomic information is spatio-temporally maintained and regulated in cells, through generations of organisms and individuals, has become a main issue for biological and medical sciences where an interdisciplinary effort, together with physico-mathematical sciences, is necessary. Physico-chemical constraints and nanoscopic scales of these systems impose indeed complex mechanisms challenging our understanding on biological (genomic and epigenomic) processes and functions.
Our methods are based on mathematical and physical modeling, by understanding the principles of genome functions, designing efficient algorithms for processing streams of data constantly growing, and physical models to describe genome structure and dynamics.
The expertise of this integrated project (PI) called “DNA and Genomes” is in the design of efficient algorithms to analyze the deluge of DNA data available today in all life domains and a number of social-economic activities (health, environment, agriculture, food …); and in modeling and understanding the very principles of genome organization, regulation and mechanisms using mathematical and physical approaches. .
Areas of expertise where NUMEV community is particularly visible are: (1) evolutionary, comparative and functional genomics, (2) population genetics, and (3) theoretical biological physics of DNA and chromosomes (4) analysis of Next Generation Sequencing data (NGS).
A number of collaborations exist between the communities of NUMEV and biology (LABEX EpiGenMed, CEMEB and AGRO as well as the Pole Rabelais and Bio-Campus) in Montpellier, France and Abroad, with particular applications in cancer, HIV-AIDS and other infectious pathogens, crop agronomy and management of invasive and pest populations.