Partners:
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| LIRMM - CNRS / UM2 | ISEM - CNRS / UM2 | LBBE - INRIA / CNRS |
Description:
The main objective of this project is to provide new models, algorithms and tools to increase significantly the knowledge on the evolution of gene in genomes. More particularly, we aim at disentangling the various events that together constitute the history of genes. In the same time we aim at inferring the relationship between the major groups of living organisms. For instance, we hope to make decisive progress on the early history of the different bacterial groups and on the parental relationship of the early eukaryotes. Global knowledge on gene transfers, duplications and losses events, e.g. average rate in specific lineages, will also be obtained in the process.
All knowledge inferred by methods proposed during the project will be stored in the project database and made available through a Web portal. By this mean, we will encourage the use of the inferred knowledge and developed software.
We hope to provide relevant models and efficient algorithms to enable the necessary computational scale up hoped by biologists to cope with the high-throughput data produced by the genome sequencing projects.
We also hope to design relevant data exploration algorithms and visualization and navigation software that will be reusable in other platforms or web sites dedicated to gene evolution to ease the discovery of new knowledge in the field.
From the computer science point of view, we hope to increase the knowledge on tree combinatorics and to provide new tree reconciliation algorithms that will be useful in other scientific areas where the tree structure is a basic model.
The final objectives of this project are to understand the evolutionary mechanisms underlying the history of genes found in sequenced genomes, and ultimately to unravel the history of the early branches of life, e.g. relationships between the major groups of bacteria, archaebacteria and first eukaryotes.
Supports:
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| Emerging domains |
Affaires Européennes et Internationales | Région Languedoc-Rousillon |
