>YCR057C PWP2 SGDID:S000000653, Chr III from 223224-220453, reverse
            complement, Verified ORF, "Conserved 90S pre-ribosomal
            component essential for proper endonucleolytic cleavage
            of the 35 S rRNA precursor at A0, A1, and A2 sites;
            contains eight WD-repeats; PWP2 deletion leads to defects
            in cell cycle and bud morphogenesis"
          Length = 923

 Score =  221 bits (562), Expect = 3e-61
 Identities = 186/721 (25%), Positives = 315/721 (43%), Gaps = 133/721 (18%)

Query: 358  WRY--KRIYYCNQEKNEEVIRSCFNKEKDIFVIAFSSGRFGIYSTPDMISLYXXXXXXXX 415
            WR   K  +Y NQ K + V    F+    +  + F+SG F +Y  PD   +         
Sbjct: 248  WRITKKHFFYANQAKVKCVT---FHPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNP 304

Query: 416  XXXXXXXXXGEWIALGEGNNGTIIIWEWKSESYILKQNTTNKNVKCVRFSPIISHLKIGS 475
                     GEW+A G    G ++++EW+SESYILKQ     +   + +SP         
Sbjct: 305  VNTVSVNQTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSP--------- 355

Query: 476  HIIDNSSTYHESDNFTSKFVIVTGNEDGTIKLYDYLSFINFVTFTAHTNTVTDICFLPQG 535
               D S              +VT +EDG IK++D  S     TF  HT++VT + F  +G
Sbjct: 356  ---DGSR-------------VVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKRG 399

Query: 536  NAFISCSLDGTVRAFDLLRYRNFKIYTPDVITDLNHYSNNMNDLNSSGKKKVDKKLNVQF 595
                S SLDGTVRA+DL+RYRNF+ +T                    G ++      +QF
Sbjct: 400  QVMFSSSLDGTVRAWDLIRYRNFRTFT--------------------GTER------IQF 433

Query: 596  LCVGVNISGNIVAAGGRGNEYVVYIWNVQTGKCIDKLFGHNSPIIKICFSTNLKNEGVIA 655
             C+ V+ SG +V AG   N + +++W+VQTG+ +D L GH  P+  + FS   +   V+A
Sbjct: 434  NCLAVDPSGEVVCAGSLDN-FDIHVWSVQTGQLLDALSGHEGPVSCLSFS---QENSVLA 489

Query: 656  SCSWSKNVLIWDLYARQNKGSKYEEITTSHDISYMCFDPRGNDILAVCTLSCKIMFWDIS 715
            S SW K + IW ++ R     + E I    D+  +   P G ++ AV TL  +I  ++I 
Sbjct: 490  SASWDKTIRIWSIFGR---SQQVEPIEVYSDVLALSMRPDGKEV-AVSTLKGQISIFNIE 545

Query: 716  IQEVVGTIEGARDIKRGRLLGEQFGAIPXXXXXXXXXXSLNNVDEESMYEEDLEDQGNNT 775
              + VG I+  +DI  GR   ++F A                                N+
Sbjct: 546  DAKQVGNIDCRKDIISGRFNQDRFTA-------------------------------KNS 574

Query: 776  IVNQNCYFTSIDYIHNGNYIVGCANCSVSLYIYDTNLYLLIKIIDLTKNYCVDGIKREIS 835
               ++ +FT+I Y  +G  IV   N + S+ +YD    +L+K   +++N  ++G    ++
Sbjct: 575  --ERSKFFTTIHYSFDGMAIVAGGN-NNSICLYDVPNEVLLKRFIVSRNMALNGTLEFLN 631

Query: 836  TRYLTSEGTHIYELDISDEEGDIYLDNYKIMNRKKKQNLLPGQINEDYLNSKLKKYKFLL 895
            ++ +T  G+    LD+ D+ G    +N  + +R    N LPG      L+++  + +  +
Sbjct: 632  SKKMTEAGS----LDLIDDAG----ENSDLEDR--IDNSLPGSQRGGDLSTRKMRPEVRV 681

Query: 896  NQLHISGDDRHIAVACNTGLYVFTKDYQYQYIPSIKNIYKGLISPNIYVPKFLTQNVXXX 955
              +  S      A A   GL +++ +                    ++ P  L  +V   
Sbjct: 682  TSVQFSPTANAFAAASTEGLLIYSTN-----------------DTILFDPFDLDVDVTPH 724

Query: 956  XXXXXXXXXEYMKAFILSLALNNYENILEVYENIPYNIIPLCVKVLTKPFLFILINFIKT 1015
                     +++ A +++  LN    I +VYE IP   IPL    +   +L  ++ FI  
Sbjct: 725  STVEALREKQFLNALVMAFRLNEEYLINKVYEAIPIKEIPLVASNIPAIYLPRILKFIGD 784

Query: 1016 LLINDTIKHIHLHLFYLNSLFTTHFNVFLNNDFYNHMNNNKSIKN-----SQDKIKTSTQ 1070
              I    +HI  +L ++ +L +     ++N   Y      +SI+      +++ + T+T 
Sbjct: 785  FAIES--QHIEFNLIWIKALLSAS-GGYINEHKYLFSTAMRSIQRFIVRVAKEVVNTTTD 841

Query: 1071 N 1071
            N
Sbjct: 842  N 842

 Score =  123 bits (309), Expect = 6e-32
 Identities = 73/263 (27%), Positives = 132/263 (50%), Gaps = 26/263 (9%)

Query: 3   NYTLSNICGCFYTGGKILFSNDGNSLFVPVSNRINIYDLSNNSCNTLKSESRNDIRHITI 62
           ++  SN+ G  Y  G I FS+DG  L  PV NR++++DL NN   T + E R +I  I +
Sbjct: 4   DFKFSNLLGTVYRQGNITFSDDGKQLLSPVGNRVSVFDLINNKSFTFEYEHRKNIAAIDL 63

Query: 63  HPSMEIIITIDKFGYGCVINLLKDQIISRILFKSKTGVVTSFNYNNMLTPQEEQDVVNSA 122
           +    ++I+ID+ G   ++N     ++    FK K   V                     
Sbjct: 64  NKQGTLLISIDEDGRAILVNFKARNVLHHFNFKEKCSAV--------------------- 102

Query: 123 MFTNSGKYFLITVGRRVVIWKSPCKQNNYK---LIKYNDICFHSLNVISIDISTDDKYFL 179
            F+  G+ F +  GR + IWK+P    + +    +++     H  ++ S+  S D ++ L
Sbjct: 103 KFSPDGRLFALASGRFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDSRFIL 162

Query: 180 TTSYDMTIRIHTV-KKEKKIKPTILGGNKTTIVGAFFSKNGNFIFSVNKSGLIIIWSYEA 238
           TTS D++ +I +V  +EK +  T   G++  ++GAFFS +   I++V+K G + +W +  
Sbjct: 163 TTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYTVSKDGAVFVWEFTK 222

Query: 239 QTGVDEKCENFEAEKVYE-DVSR 260
           +   D+  E+ + +K  E D+S+
Sbjct: 223 RPSDDDDNESEDDDKQEEVDISK 245

 Score = 27.7 bits (60), Expect = 0.004
 Identities = 53/289 (18%), Positives = 112/289 (38%), Gaps = 34/289 (11%)

Query: 463 RFSPIISHLKIGSHIIDNSSTYHESDNFTSKFVIVTGNEDGTIKLYDYLSF---INFVTF 519
           +F+P + H     H  D +S     D   S+F++ T ++D + K++   S    +   TF
Sbjct: 132 QFAPFVRHRVHAGHFQDITSLTWSQD---SRFILTT-SKDLSAKIWSVDSEEKNLAATTF 187

Query: 520 TAHTNTVTDICFLPQGNAFISCSLDGTVRAFDLLRY------RNFKIYTPDVITDLNHYS 573
             H + V    F        + S DG V  ++  +          +        D++ YS
Sbjct: 188 NGHRDYVMGAFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYS 247

Query: 574 NNMNDLNSSGKKKVDKKLNVQFLCVGVNISGNIVAAGGRGNEYVVYIWNVQTGKCIDKLF 633
             +       KK        +  CV  + +  ++A G    E+ +Y  ++     I +L 
Sbjct: 248 WRIT------KKHFFYANQAKVKCVTFHPATRLLAVGFTSGEFRLY--DLPDFTLIQQLS 299

Query: 634 GHNSPIIKICFSTNLKNEGVIASCSWSKNVLIWDLYARQNKGSKYEEITTSHDISYMCFD 693
              +P+  +  S N   E +    S    +L+++  +      +     +++ ++Y    
Sbjct: 300 MGQNPVNTV--SVNQTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAY---S 354

Query: 694 PRGNDILAVCTLSCKIMFWDI-------SIQEVVGTIEGARDIKRGRLL 735
           P G+ ++   +   KI  WDI       + +E   ++   +  KRG+++
Sbjct: 355 PDGSRVV-TASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQVM 402

 Score = 24.3 bits (51), Expect = 0.047
 Identities = 11/30 (36%), Positives = 17/30 (56%)

Query: 268 DVSMDDNKGDEDVSRDDNKSDEDVSRDDEN 297
           D SM+D   D+D     + +DED   ++EN
Sbjct: 853 DGSMEDGAADDDEVLLKDDADEDNEENEEN 882

 Score = 23.5 bits (49), Expect = 0.081
 Identities = 18/71 (25%), Positives = 32/71 (45%), Gaps = 3/71 (4%)

Query: 234 WSYEAQTGVDEKCENFEA---EKVYEDVSRDDNKGDEDVSMDDNKGDEDVSRDDNKSDED 290
           ++Y      D   E+  A   E + +D + +DN+ +E+  +     DE+     N  D  
Sbjct: 844 YTYRFLVSTDGSMEDGAADDDEVLLKDDADEDNEENEENDVVMESDDEEGWIGFNGKDNK 903

Query: 291 VSRDDENISSD 301
           +   +EN SSD
Sbjct: 904 LPLSNENDSSD 914

 Score = 22.7 bits (47), Expect = 0.14
 Identities = 15/60 (25%), Positives = 26/60 (43%), Gaps = 5/60 (8%)

Query: 505 IKLYDYLSFINFVTFTAHTNTVTDICFLPQGNAFISCSLDG-----TVRAFDLLRYRNFK 559
           + ++D ++  +F     H   +  I    QG   IS   DG       +A ++L + NFK
Sbjct: 37  VSVFDLINNKSFTFEYEHRKNIAAIDLNKQGTLLISIDEDGRAILVNFKARNVLHHFNFK 96

 Score = 21.9 bits (45), Expect = 0.23
 Identities = 17/74 (22%), Positives = 31/74 (41%), Gaps = 4/74 (5%)

Query: 161 FHSLNVISIDISTDDKYFLTTSYDMTIRIHTVKKEKKIKPTILGGNKTTIVGAFFSKNGN 220
           F S N  S+  S D    +T S D  I++  +     +       + +++    F+K G 
Sbjct: 345 FDSTN--SLAYSPDGSRVVTASEDGKIKVWDITSGFCL--ATFEEHTSSVTAVQFAKRGQ 400

Query: 221 FIFSVNKSGLIIIW 234
            +FS +  G +  W
Sbjct: 401 VMFSSSLDGTVRAW 414

 Score = 20.8 bits (42), Expect = 0.52
 Identities = 10/40 (25%), Positives = 22/40 (55%), Gaps = 1/40 (2%)

Query: 162 HSLNVISIDISTDDKYFLTTSYDMTIRIHTV-KKEKKIKP 200
           H   V  +  S ++    + S+D TIRI ++  + ++++P
Sbjct: 472 HEGPVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEP 511

 Score = 20.4 bits (41), Expect = 0.68
 Identities = 18/75 (24%), Positives = 34/75 (45%), Gaps = 7/75 (9%)

Query: 203 LGGNKTTIVGAFFSKNGNFIFSVNKSGLIIIWSYEAQTGVDEKCENFEAEKVYEDVSRDD 262
           L G++  +    FS+  + + S +    I IWS      +  + +  E  +VY DV    
Sbjct: 469 LSGHEGPVSCLSFSQENSVLASASWDKTIRIWS------IFGRSQQVEPIEVYSDVLALS 522

Query: 263 NKGD-EDVSMDDNKG 276
            + D ++V++   KG
Sbjct: 523 MRPDGKEVAVSTLKG 537

 Score = 20.0 bits (40), Expect = 0.89
 Identities = 11/37 (29%), Positives = 19/37 (51%), Gaps = 3/37 (8%)

Query: 831 KREISTRYLTSEGTHIYELDISDEEGDIYLDNYKIMN 867
           ++ I+   L  +GT +  +D   E+G   L N+K  N
Sbjct: 55  RKNIAAIDLNKQGTLLISID---EDGRAILVNFKARN 88

Lambda     K      H
   0.320    0.137    0.408 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 1
Number of Hits to DB: 2648
Number of extensions: 166
Number of successful extensions: 36
Number of sequences better than 10.0: 1
Number of HSP's gapped: 17
Number of HSP's successfully gapped: 15
Length of query: 1121
Length of database: 923
Length adjustment: 45
Effective length of query: 1076
Effective length of database: 878
Effective search space:   944728
Effective search space used:   944728
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 31 (17.2 bits)
S2: 31 (16.5 bits)