>YMR167W MLH1 SGDID:S000004777, Chr XIII from 594885-597194,
           Verified ORF, "Protein required for mismatch repair in
           mitosis and meiosis, postmeiotic segregation, and spore
           viability; forms a complex with Pms1p and Msh2p to
           repair mismatched DNA; human homolog is associated with
           hereditary non-polyposis colon cancer"
          Length = 769

 Score =  196 bits (499), Expect = 4e-54
 Identities = 98/202 (48%), Positives = 146/202 (72%), Gaps = 2/202 (0%)

Query: 49  RIIKLAEEDINRIAAGEVIIRPCNALKELVENSLDANSSSISIHLNKGGLKSLQIIDDGD 108
           RI  L    +N+IAAGE+II P NALKE++ENS+DAN++ I I + +GG+K LQI D+G 
Sbjct: 4   RIKALDASVVNKIAAGEIIISPVNALKEMMENSIDANATMIDILVKEGGIKVLQITDNGS 63

Query: 109 GIHKEDLRIVCERFTTSKISNHKDIRNIKTFGFRGEALASISHVSYLTITSKKRNSPFCY 168
           GI+K DL I+CERFTTSK+   +D+  I+T+GFRGEALASISHV+ +T+T+K +     +
Sbjct: 64  GINKADLPILCERFTTSKLQKFEDLSQIQTYGFRGEALASISHVARVTVTTKVKEDRCAW 123

Query: 169 TCNYKDGKPTQDEPTVCSGKNGTIIRFDDLFYNMPARLKTM-NPNDEYNKCLEVLQKYAI 227
             +Y +GK   + P   +GK+GT I  +DLF+N+P+RL+ + + NDEY+K L+V+ +YAI
Sbjct: 124 RVSYAEGK-MLESPKPVAGKDGTTILVEDLFFNIPSRLRALRSHNDEYSKILDVVGRYAI 182

Query: 228 HYPNVSFTCKKWLSNTVDLNTQ 249
           H  ++ F+CKK+  +   L+ +
Sbjct: 183 HSKDIGFSCKKFGDSNYSLSVK 204

 Score =  116 bits (290), Expect = 7e-30
 Identities = 150/631 (23%), Positives = 247/631 (39%), Gaps = 98/631 (15%)

Query: 410  IQKVYGRNISKELSTIFLKEKSIPTFFKCYGLISNPTYNGKKGCY-IFFINDRLVESNII 468
            I+ V+ ++++  L T  + +          G + N  +  KK    IFFIN+RLV  +++
Sbjct: 213  IRTVFNKSVASNLITFHISKVEDLNLESVDGKVCNLNFISKKSISPIFFINNRLVTCDLL 272

Query: 469  KKSCENQYSNFLAKGNYPWIYLSLRLKYDIVDINVHPTKKEVHFLYQEEISMLIGKKIQE 528
            +++  + YSN+L KGN P+IYL + +    VD+NVHPTK+EV FL Q+EI   I  ++  
Sbjct: 273  RRALNSVYSNYLPKGNRPFIYLGIVIDPAAVDVNVHPTKREVRFLSQDEIIEKIANQLHA 332

Query: 529  FLKSFHNMRTFNITGEKLLQTKLDINSSMLEIKKEDKELSKLRQGLLHDNN--------N 580
             L +    RTF      +   K +      +  + D+    LRQ  + +N+         
Sbjct: 333  ELSAIDTSRTFK--ASSISTNKPESLIPFNDTIESDRNRKSLRQAQVVENSYTTANSQLR 390

Query: 581  VIKRQIDTKRVRTDFKQITLTNYFVKKE--NMIDDHLDNNKSVDMLYNGDHNGDAKQIDL 638
              KRQ + K VR D  Q  +T++    +  N          S   + N  H+ +A+++ L
Sbjct: 391  KAKRQ-ENKLVRIDASQAKITSFLSSSQQFNFEGSSTKRQLSEPKVTNVSHSQEAEKLTL 449

Query: 639  YEHNDEYNKTYDQTNIRANLHMXXXXXXXXXXXXXXXXXXXXGPNSVLYNTQIDKHISNK 698
                +E  +  D   I  N                         N++         IS  
Sbjct: 450  ----NESEQPRDANTINDNDLKDQPKKKQKLGDYKVPSIADDEKNAL--------PISKD 497

Query: 699  IYDRKYPCEADEI--SSIKKLKMIXXXXXXXXXXXXXXNSIYVGPVDNMHSL--IQYXXX 754
             Y R  P E   +  +SIKKL+                N  YVG VD    L  IQ+   
Sbjct: 498  GYIR-VPKERVNVNLTSIKKLREKVDDSIHRELTDIFANLNYVGVVDEERRLAAIQHDLK 556

Query: 755  XXXXXXXXXXXEVTYQSILNRLGKIPPFEFDPPIPLYDLLLVAVNNSYSGFYENPNYANK 814
                       E+ YQ  L                  D++L    N  S F E  + A+K
Sbjct: 557  LFLIDYGSVCYELFYQIGLTDFANFGKINLQSTNVSDDIVLY---NLLSEFDELNDDASK 613

Query: 815  NIEKVCNELEQIFYTYNEMYSDYFSI-IIEDGC--------IVTFPACCGEYFPGQEFLP 865
              EK+ +++    +  + M ++Y+SI ++ DG         + + P     Y P    LP
Sbjct: 614  --EKIISKI----WDMSSMLNEYYSIELVNDGLDNDLKSVKLKSLPLLLKGYIPSLVKLP 667

Query: 866  FLFLRLATQIDYSKEINCINGICYLLANFYSKITLLNDKEWTYQDDLLMIQEKEKEIQML 925
            F   RL  ++D+  E  C++GI   +A                   LL I +   ++   
Sbjct: 668  FFIYRLGKEVDWEDEQECLDGILREIA-------------------LLYIPDMVPKV--- 705

Query: 926  LXXXXXXXXXXXXXXQHYDETNLDYILGDESVVDINKHLSVSRNINLVFEKYFFPMIQLN 985
                               +T+   +  DE    IN+      +I+ + E   FP I+  
Sbjct: 706  -------------------DTSDASLSEDEKAQFINR----KEHISSLLEHVLFPCIKRR 742

Query: 986  NIMKIPTTFSNNGYIIELTSLNQLYKIFERC 1016
             +   P     +  ++E+ +L  LYK+FERC
Sbjct: 743  FL--APRHILKD--VVEIANLPDLYKVFERC 769

 Score = 21.6 bits (44), Expect = 0.23
 Identities = 8/13 (61%), Positives = 9/13 (69%)

Query: 638 LYEHNDEYNKTYD 650
           L  HNDEY+K  D
Sbjct: 163 LRSHNDEYSKILD 175

 Score = 18.5 bits (36), Expect = 1.9
 Identities = 13/65 (20%), Positives = 29/65 (44%), Gaps = 12/65 (18%)

Query: 46  GDRRIIKLAEEDINRIAAGE------------VIIRPCNALKELVENSLDANSSSISIHL 93
           GD ++  +A+++ N +   +            V +     L+E V++S+    + I  +L
Sbjct: 477 GDYKVPSIADDEKNALPISKDGYIRVPKERVNVNLTSIKKLREKVDDSIHRELTDIFANL 536

Query: 94  NKGGL 98
           N  G+
Sbjct: 537 NYVGV 541

Lambda     K      H
   0.319    0.137    0.411 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 1
Number of Hits to DB: 1759
Number of extensions: 88
Number of successful extensions: 12
Number of sequences better than 10.0: 1
Number of HSP's gapped: 9
Number of HSP's successfully gapped: 9
Length of query: 1016
Length of database: 769
Length adjustment: 43
Effective length of query: 973
Effective length of database: 726
Effective search space:   706398
Effective search space used:   706398
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 30 (16.7 bits)
S2: 30 (16.2 bits)