>YLR197W SIK1 SGDID:S000004187, Chr XII from 546099-547613, Verified
           ORF, "Essential evolutionarily-conserved nucleolar
           protein component of the box C/D snoRNP complexes that
           direct 2'-O-methylation of pre-rRNA during its
           maturation; overexpression causes spindle orientation
           defects"
          Length = 504

 Score =  306 bits (784), Expect = 1e-87
 Identities = 168/436 (38%), Positives = 267/436 (61%), Gaps = 10/436 (2%)

Query: 5   YILFECSAGYFLLKIE-EWEQIGNT-EELEKKILKSDIFHQMVEFCAFIPFETAERALDN 62
           Y+LFE   GY + K++ + + IG+  +E++++I     F +++E  +F PF+ A  AL+N
Sbjct: 6   YLLFEEPTGYAVFKVKLQQDDIGSRLKEVQEQINDFGAFTKLIELVSFAPFKGAAEALEN 65

Query: 63  LLNINEGKATTFLLSFLEQNLP---NNKNKYELGVADINLGKYLSNVG--FNIIHNNNVL 117
             +I+EG  +  L + L+ NLP   + K    L ++D NLG  +       + I N    
Sbjct: 66  ANDISEGLVSESLKAILDLNLPKASSKKKNITLAISDKNLGPSIKEEFPYVDCISNELAQ 125

Query: 118 ELFRACRQHYLKKISTYVNNIDIDIKHFNIGLGHSYSRSKLKLDPRKQDKSIINSIGTIE 177
           +L R  R H  K      +    D++   +GLGH+YSR+K+K   +K D  II +I  ++
Sbjct: 126 DLIRGVRLHGEKLFKGLQSG---DLERAQLGLGHAYSRAKVKFSVQKNDNHIIQAIALLD 182

Query: 178 SLDKNINLFSMRVIEWYSWHFPELKKIVTDVCMYCKLVNLIQIKEKFDFDTYEDKINDIT 237
            LDK+IN F+MRV EWY WHFPEL K+V D   + KLV  I+ K   + D+  D    + 
Sbjct: 183 QLDKDINTFAMRVKEWYGWHFPELAKLVPDNYTFAKLVLFIKDKASLNDDSLHDLAALLN 242

Query: 238 QNEDMTKNICKVANLSIGQELTEEDLTNILNFSNEVINLSNTRNILWNYLDNKLNIVSPN 297
           ++  + + +   A +S+GQ+++E D+ N+  F+  V +L++ R  L++YL  K++ V+PN
Sbjct: 243 EDSGIAQRVIDNARISMGQDISETDMENVCVFAQRVASLADYRRQLYDYLCEKMHTVAPN 302

Query: 298 LKELLGNTLSARLISHAGSLVNLAKCPSSSIQIFGSEKALFNSLKGNKKTPKYGILYNSS 357
           L EL+G  + ARLISHAGSL NL+K  +S++QI G+EKALF +LK    TPKYG++Y+S 
Sbjct: 303 LSELIGEVIGARLISHAGSLTNLSKQAASTVQILGAEKALFRALKTKGNTPKYGLIYHSG 362

Query: 358 YISKTPIQLKGRMSRYLSCKSAMAARIDSFSDYPTNSYGLIFKKQLEHKIQHMVKGVKLS 417
           +ISK   + KGR+SRYL+ K +MA+RID++S+ P+N +G + KKQ+E +++    G    
Sbjct: 363 FISKASAKNKGRISRYLANKCSMASRIDNYSEEPSNVFGSVLKKQVEQRLEFYNTGKPTL 422

Query: 418 KNIDYINEAEQIYRNE 433
           KN   I EA ++Y  +
Sbjct: 423 KNELAIQEAMELYNKD 438

 Score = 16.9 bits (32), Expect = 2.1
 Identities = 7/16 (43%), Positives = 10/16 (62%)

Query: 523 INDDLNGDVNEELNDD 538
           +NDD   D+   LN+D
Sbjct: 229 LNDDSLHDLAALLNED 244

 Score = 15.0 bits (27), Expect = 7.9
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 521 DQINDDLN 528
           DQ++ D+N
Sbjct: 182 DQLDKDIN 189

Lambda     K      H
   0.316    0.135    0.386 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 1
Number of Hits to DB: 624
Number of extensions: 33
Number of successful extensions: 7
Number of sequences better than 10.0: 1
Number of HSP's gapped: 3
Number of HSP's successfully gapped: 3
Length of query: 594
Length of database: 504
Length adjustment: 36
Effective length of query: 558
Effective length of database: 468
Effective search space:   261144
Effective search space used:   261144
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 27 (15.2 bits)
S2: 27 (15.0 bits)