>YDR172W SUP35 SGDID:S000002579, Chr IV from 808320-810377, Verified
           ORF, "Translation termination factor eRF3; altered
           protein conformation creates the [PSI(+)] prion, a
           dominant cytoplasmically inherited protein aggregate
           that alters translational fidelity and creates a
           nonsense suppressor phenotype"
          Length = 685

 Score =  428 bits (1100), Expect = e-124
 Identities = 230/502 (45%), Positives = 319/502 (63%), Gaps = 19/502 (3%)

Query: 58  KEEEDINGSEIVEDEN----VNDIEEKISKLVLNDDNDIMKDDVEELQEKVEDKKIKMAE 113
           KEE+ +   E  E+++    V D++   S    N+ N    D + + QE+  D ++    
Sbjct: 195 KEEKPVQTEEKTEEKSELPKVEDLKISESTHNTNNANVTSADALIKEQEEEVDDEVVNDM 254

Query: 114 VDPRPHLNIIFIGHVDAGKSTACGNILYILGYVDDRTIEKYEREAKEKSRESWFLAFIMD 173
              + H+++IF+GHVDAGKST  GN+LY+ G VD RTIEKYEREAK+  R+ W+L+++MD
Sbjct: 255 FGGKDHVSLIFMGHVDAGKSTMGGNLLYLTGSVDKRTIEKYEREAKDAGRQGWYLSWVMD 314

Query: 174 INEEERQKGKTVEVGRAHFETKDRRFTILDAPGHKNFIPNMISGAAQADIGVLIISARKG 233
            N+EER  GKT+EVG+A+FET+ RR+TILDAPGHK ++  MI GA+QAD+GVL+ISARKG
Sbjct: 315 TNKEERNDGKTIEVGKAYFETEKRRYTILDAPGHKMYVSEMIGGASQADVGVLVISARKG 374

Query: 234 EFETGFERGGQTREHTLLARTLGINQLIVAINKMDDPTCNWSESRYEEIQKKITPYIKSC 293
           E+ETGFERGGQTREH LLA+T G+N+++V +NKMDDPT NWS+ RY++    ++ ++++ 
Sbjct: 375 EYETGFERGGQTREHALLAKTQGVNKMVVVVNKMDDPTVNWSKERYDQCVSNVSNFLRAI 434

Query: 294 GYNINKDVFFVPISGLTGQNLSEHVSDKNSKIYDPRASWYDLSKPTLFNILNSLPPPPWD 353
           GYNI  DV F+P+SG +G NL +HV  K          WY  + PTL   L+++      
Sbjct: 435 GYNIKTDVVFMPVSGYSGANLKDHVDPK-------ECPWY--TGPTLLEYLDTMNHVDRH 485

Query: 354 ENGPLRIPLLEGYKDNGIIAIGKIESGTLYGNNMNCTLMPNXXXXXXMNVFLE-DDEVPY 412
            N P  +P+    KD G I  GKIESG +     +  LMPN       N++ E ++EV  
Sbjct: 486 INAPFMLPIAAKMKDLGTIVEGKIESGHI-KKGQSTLLMPNKTAVEIQNIYNETENEVDM 544

Query: 413 AKPGENVRVRLFGVEEDQISKGFVLCDSINLCSVVHEFIGRVAIVELLEHKPIITAGYFC 472
           A  GE V++R+ GVEE+ IS GFVL    N    V +F+ ++AIVEL   K II AG+ C
Sbjct: 545 AMCGEQVKLRIKGVEEEDISPGFVLTSPKNPIKSVTKFVAQIAIVEL---KSIIAAGFSC 601

Query: 473 IFHAHTACEEIQFVEMLEVIDXXXXXXXXXXXXXXSDCI-VTAHFLLSNPVCVEVYDNLP 531
           + H HTA EE+  V++L  ++                 + V A      PVCVE Y + P
Sbjct: 602 VMHVHTAIEEVHIVKLLHKLEKGTNRKSKKPPAFAKKGMKVIAVLETEAPVCVETYQDYP 661

Query: 532 QLGRFTLRDQGKTIAIGKILEL 553
           QLGRFTLRDQG TIAIGKI+++
Sbjct: 662 QLGRFTLRDQGTTIAIGKIVKI 683

Lambda     K      H
   0.318    0.138    0.409 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 1
Number of Hits to DB: 1052
Number of extensions: 53
Number of successful extensions: 14
Number of sequences better than 10.0: 1
Number of HSP's gapped: 2
Number of HSP's successfully gapped: 2
Length of query: 555
Length of database: 685
Length adjustment: 37
Effective length of query: 518
Effective length of database: 648
Effective search space:   335664
Effective search space used:   335664
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)