>YPR019W CDC54 SGDID:S000006223, Chr XVI from 596747-599548,
           Verified ORF, "Essential helicase component of
           heterohexameric MCM2-7 complexes which bind
           pre-replication complexes on DNA and melt the DNA prior
           to replication; accumulates in the nucleus in G1;
           homolog of S. pombe Cdc21p"
          Length = 933

 Score =  436 bits (1120), Expect = e-126
 Identities = 220/494 (44%), Positives = 327/494 (66%), Gaps = 31/494 (6%)

Query: 228 LYKLIIEYPSDCISEIDKIISTKYNSLLALVLEGDTRSSSSDKYPLSSTKQDYCRVRFFN 287
           LY  ++ YP + IS +D+ I    + +++L+++ +        Y L   +  + +VR +N
Sbjct: 257 LYHQLLNYPQEVISIMDQTIK---DCMVSLIVDNNL------DYDLDEIETKFYKVRPYN 307

Query: 288 KKHKDTPRKLGPNQIETLVCVKGVIIRCSNIIPEMTMAAFKCTSKKRIGVNNYEKCNEEV 347
                  R+L PN I+ L+ +KG+++R + +IP+M +A FKC             C+  +
Sbjct: 308 VGSCKGMRELNPNDIDKLINLKGLVLRSTPVIPDMKVAFFKCNV-----------CDHTM 356

Query: 348 YEHVIQGEVQEPVTCS--NCNNKNTFELWHNNCCFSSKQLIKLSEVTEHLKQGETPQSIS 405
              + +G +QEP  C   +CN  N+  L HN C F+ KQ+IKL E  + +  G+TP SIS
Sbjct: 357 AVEIDRGVIQEPARCERIDCNEPNSMSLIHNRCSFADKQVIKLQETPDFVPDGQTPHSIS 416

Query: 406 IYAYDDLIDYTKPGDTVELTGILKASPVRLNPRSRCYNSVHRTYINVIHIKKENKQKMKL 465
           +  YD+L+D  + GD +E+TG  ++ P+R N R R   S+++TY++V+H+KK + +++ +
Sbjct: 417 LCVYDELVDSCRAGDRIEVTGTFRSIPIRANSRQRVLKSLYKTYVDVVHVKKVSDKRLDV 476

Query: 466 TEQNDTANIILKRNEDGTVEENFEKLNEQGNLLFTTEVIQKMEQLSKDPNIYQRLVDSIA 525
                   ++  + +   VEE  +          T + + K+ +++   ++Y  L  SIA
Sbjct: 477 DTSTIEQELMQNKVDHNEVEEVRQ---------ITDQDLAKIREVAAREDLYSLLARSIA 527

Query: 526 PSIYGREDIKKGLLCQLFGGSKITDKYNNKYRSEIHILLCGDPSTAKSQLLHYVHKLSPR 585
           PSIY  ED+KKG+L QLFGG+  T     +YR +I+ILLCGDPST+KSQ+L YVHK++PR
Sbjct: 528 PSIYELEDVKKGILLQLFGGTNKTFTKGGRYRGDINILLCGDPSTSKSQILQYVHKITPR 587

Query: 586 GIYTSGKGSSSVGLTAFISKDSETKEYILESGAVVLSDKGICCIDEFDKMDDSARAILHE 645
           G+YTSGKGSS+VGLTA+I++D +TK+ +LESGA+VLSD G+CCIDEFDKM DS R++LHE
Sbjct: 588 GVYTSGKGSSAVGLTAYITRDVDTKQLVLESGALVLSDGGVCCIDEFDKMSDSTRSVLHE 647

Query: 646 VMEQQTVTIAKAGIVATLNARTSILASANPINSRYDKNKAVVENINLPPSLFSRFDLIYL 705
           VMEQQT++IAKAGI+ TLNAR+SILASANPI SRY+ N  V ENI+LPP L SRFDL+YL
Sbjct: 648 VMEQQTISIAKAGIITTLNARSSILASANPIGSRYNPNLPVTENIDLPPPLLSRFDLVYL 707

Query: 706 VIDQANEDEDRKLA 719
           V+D+ +E  DR+LA
Sbjct: 708 VLDKVDEKNDRELA 721

 Score = 72.0 bits (175), Expect = 2e-16
 Identities = 54/181 (29%), Positives = 88/181 (48%), Gaps = 10/181 (5%)

Query: 827  LALYIAYCRITCNPXXXXXXXXXXXXXXXXMR-----CKEGTKSPTASPRQLEGLVRLSQ 881
            L +YI+Y +   +P                MR      +   K  TA+ RQLE ++RL++
Sbjct: 747  LTMYISYAKEHIHPIITEAAKTELVRAYVGMRKMGDDSRSDEKRITATTRQLESMIRLAE 806

Query: 882  SLAKMKLKRVVSPEEANEAVRLMNIATFQSLIDPLSGRIDFDQVNLGQTSQHKKKSDLIK 941
            + AKMKLK VV  E+  EAVRL+  A      DP +G+ID + V  G++   +K  + + 
Sbjct: 807  AHAKMKLKNVVELEDVQEAVRLIRSAIKDYATDPKTGKIDMNLVQTGKSVIQRKLQEDLS 866

Query: 942  DIIMNALVLKNMTKDELLTHCHETIMNDPQHTTS-MDRKSFEEAFYDLEKSQEITRLCSG 1000
              IMN  VLK+   D +    +E I    +H+   ++    +EA   L++  ++  L  G
Sbjct: 867  REIMN--VLKDQASDSM--SFNELIKQINEHSQDRVESSDIQEALSRLQQEDKVIVLGEG 922

Query: 1001 L 1001
            +
Sbjct: 923  V 923

 Score = 16.9 bits (32), Expect = 6.8
 Identities = 8/28 (28%), Positives = 14/28 (50%)

Query: 88  KCARADIGDVGREAFMEDVESGRLPHFI 115
           +C+ AD   +  +   + V  G+ PH I
Sbjct: 388 RCSFADKQVIKLQETPDFVPDGQTPHSI 415

Lambda     K      H
   0.317    0.133    0.382 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 1
Number of Hits to DB: 1944
Number of extensions: 77
Number of successful extensions: 6
Number of sequences better than 10.0: 1
Number of HSP's gapped: 3
Number of HSP's successfully gapped: 3
Length of query: 1005
Length of database: 933
Length adjustment: 44
Effective length of query: 961
Effective length of database: 889
Effective search space:   854329
Effective search space used:   854329
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 31 (17.1 bits)
S2: 31 (16.5 bits)