Query= PF13_0143 Pf
Annotation|Plasmodium_falciparum_Sanger|(protein coding)
phosphoribosylpyrophosphate synthetase
(437 letters)
>YHL011C PRS3 SGDID:S000001003, Chr VIII from 81612-80650, reverse
complement, Verified ORF,
"5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase,
involved in nucleotide, histidine, and tryptophan
biosynthesis; one of a five related enzymes, which are
active as heteromultimeric complexes"
Length = 320
Score = 214 bits (546), Expect = 2e-60
Identities = 129/307 (42%), Positives = 183/307 (59%), Gaps = 10/307 (3%)
Query: 129 LSKNVADHLGTSLGRVNLKRFADGEVSMQFLESIRGKDVYII-QPTCPPVNENLIELLLM 187
L++ VA LG L LKR GEVS ES+R +D++II Q VN+ ++ELL+M
Sbjct: 17 LAELVAKRLGLQLTSSKLKRDPTGEVSFSIGESVRDQDIFIITQIGSGVVNDRVLELLIM 76
Query: 188 ISTCRRASAKKITAVIPYYGYARQDRKLSSRVPISAADVARMIEAMGVDRVVAIDLHSGQ 247
I+ + ASA++ITA+IP + YARQDRK SR PI+A +A M+ G D V+ +DLH+ Q
Sbjct: 77 INASKTASARRITAIIPNFPYARQDRKDKSRAPITAKLMADMLTTAGCDHVITMDLHASQ 136
Query: 248 IQGFFGPRVPVDNLEAQLIGLDYFTKKDLYKP-VIVSPDAGGVYRARKFQDGLNHRGIGD 306
IQGFF VPVDNL A+ + Y + Y +I+SPDAGG RA D L D
Sbjct: 137 IQGFFD--VPVDNLYAEPSVVRYIKENVNYMDSIIISPDAGGAKRAATLADRL------D 188
Query: 307 CGIAMLIKQRTKPNEIEKMDLVGNXXXXXXXXXXXXXXTSGTLCEAAKQLKKHGARRVFA 366
A++ K+R + NE+ +M LVG+ T GTL +AA+ L ++ A+ V A
Sbjct: 189 LNFALIHKERARANEVSRMVLVGDVTDKICIIVDDMADTCGTLAKAAEILLENRAKSVIA 248
Query: 367 FATHGLFSGPAIDRIEKSPLEEVVVTDTVKSNKNIDSCKKITKLSVSVLVADAIRRIHQK 426
THG+ SG AI+ I S L+ VV T+TV + I C K+ + +S ++A++IRR+H
Sbjct: 249 IVTHGVLSGRAIENINNSKLDRVVCTNTVPFEEKIKKCPKLAVIDISSVLAESIRRLHNG 308
Query: 427 ESLNDLF 433
ES++ LF
Sbjct: 309 ESISYLF 315
Score = 20.0 bits (40), Expect = 0.11
Identities = 10/28 (35%), Positives = 14/28 (50%)
Query: 33 VAMLVSTGIIGGYYISKEENRKDFRKVC 60
V +V+ G++ G I N K R VC
Sbjct: 246 VIAIVTHGVLSGRAIENINNSKLDRVVC 273
Score = 17.7 bits (34), Expect = 0.55
Identities = 10/45 (22%), Positives = 19/45 (42%)
Query: 115 MENAILFSGTSNPLLSKNVADHLGTSLGRVNLKRFADGEVSMQFL 159
M++ I+ + +AD L + ++ +R EVS L
Sbjct: 165 MDSIIISPDAGGAKRAATLADRLDLNFALIHKERARANEVSRMVL 209
Lambda K H
0.320 0.136 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 1
Number of Hits to DB: 272
Number of extensions: 14
Number of successful extensions: 7
Number of sequences better than 10.0: 1
Number of HSP's gapped: 3
Number of HSP's successfully gapped: 3
Length of query: 437
Length of database: 320
Length adjustment: 30
Effective length of query: 407
Effective length of database: 290
Effective search space: 118030
Effective search space used: 118030
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 24 (14.0 bits)
S2: 24 (13.9 bits)