>YFR052W RPN12 SGDID:S000001948, Chr VI from 252492-253316, Verified
           ORF, "Subunit of the 19S regulatory particle of the 26S
           proteasome lid; synthetically lethal with RPT1, which is
           an ATPase component of the 19S regulatory particle;
           physically interacts with Nob1p and Rpn3p"
          Length = 274

 Score = 73.6 bits (179), Expect = 5e-18
 Identities = 65/235 (27%), Positives = 111/235 (47%), Gaps = 26/235 (11%)

Query: 84  IRELLIVRGILEKGVIISIRNKDIKSFNIYIAQLFIYYFDYKDILPKSKKQNAIVGLYLL 143
           + +L+I + ILE G + SI+  +  SF  Y  QL  YYF     L +S K++ ++ LYLL
Sbjct: 52  LNDLMITKRILEVGALASIQTFNFDSFENYFNQLKPYYFSNNHKLSESDKKSKLISLYLL 111

Query: 144 YLLASNSIGDFHMTLEILP-----LEDHNDIYIKYVLNVEQNIMDGFFHHV--LTKKENI 196
            LL+ N+   FH  L+ L      LED  D  + Y + +++ +M+G +     L +  + 
Sbjct: 112 NLLSQNNTTKFHSELQYLDKHIKNLED--DSLLSYPIKLDRWLMEGSYQKAWDLLQSGSQ 169

Query: 197 PLYLYESFMDKLYTTIRFKLIDCIFASTNSIHLLYACELLKLSNQQNLNDFIIQYN---- 252
            +  ++SF D L + IR ++      S + + L     LL  +N++    F ++ N    
Sbjct: 170 NISEFDSFTDILKSAIRDEIAKNTELSYDFLPLSNIKALLFFNNEKETEKFALERNWPIV 229

Query: 253 EAK---NNQGEYNAVCEIKDNHIVCKNQTIAVQQLPSLEIINNSIGYATELERIV 304
            +K   NNQ +  A  E +  H          ++     II  ++ YA  +E IV
Sbjct: 230 NSKVYFNNQSKEKADYEDEMMH----------EEDQKTNIIEKAMDYAISIENIV 274

 Score = 16.2 bits (30), Expect = 0.94
 Identities = 21/93 (22%), Positives = 39/93 (41%), Gaps = 12/93 (12%)

Query: 158 LEILPLEDHNDIYIKYVLNVEQNIMDGFFHHVLTKKENIPLYLYESFMDKL---YTTIRF 214
           L I  L   NDIY+  ++  ++ +  G     L   +      +E++ ++L   Y +   
Sbjct: 39  LLIPDLSIQNDIYLNDLMITKRILEVG----ALASIQTFNFDSFENYFNQLKPYYFSNNH 94

Query: 215 KLIDCIFASTNSIHLLYACELLKLSNQQNLNDF 247
           KL     + ++    L +  LL L +Q N   F
Sbjct: 95  KL-----SESDKKSKLISLYLLNLLSQNNTTKF 122

Lambda     K      H
   0.323    0.141    0.407 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 1
Number of Hits to DB: 229
Number of extensions: 14
Number of successful extensions: 5
Number of sequences better than 10.0: 1
Number of HSP's gapped: 3
Number of HSP's successfully gapped: 2
Length of query: 304
Length of database: 274
Length adjustment: 26
Effective length of query: 278
Effective length of database: 248
Effective search space:    68944
Effective search space used:    68944
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 22 (13.1 bits)
S2: 22 (13.1 bits)