>YLR197W SIK1 SGDID:S000004187, Chr XII from 546099-547613, Verified
           ORF, "Essential evolutionarily-conserved nucleolar
           protein component of the box C/D snoRNP complexes that
           direct 2'-O-methylation of pre-rRNA during its
           maturation; overexpression causes spindle orientation
           defects"
          Length = 504

 Score = 82.4 bits (202), Expect = 4e-20
 Identities = 62/239 (25%), Positives = 114/239 (47%), Gaps = 5/239 (2%)

Query: 183 DDVMIEKCMETILKIDTEILNIHKYVKDIYSTKFPELDSIVYSPVEYISVVNKIRNEVDL 242
           +D  I + +  + ++D +I      VK+ Y   FPEL  +V     +  +V  I+++  L
Sbjct: 170 NDNHIIQAIALLDQLDKDINTFAMRVKEWYGWHFPELAKLVPDNYTFAKLVLFIKDKASL 229

Query: 243 KNIDFSDI---LPNTTVMAITVASS--MTTGICLPDNLLKNCISFCNEGIQLNEYRNIIL 297
            +    D+   L   + +A  V  +  ++ G  + +  ++N   F      L +YR  + 
Sbjct: 230 NDDSLHDLAALLNEDSGIAQRVIDNARISMGQDISETDMENVCVFAQRVASLADYRRQLY 289

Query: 298 LYLESKMFYLAPNVTMLLGSSLTARLISAVGSLKNLSIISSQNLIVIASTKKSLFGLSNV 357
            YL  KM  +APN++ L+G  + ARLIS  GSL NLS  ++  + ++ + K     L   
Sbjct: 290 DYLCEKMHTVAPNLSELIGEVIGARLISHAGSLTNLSKQAASTVQILGAEKALFRALKTK 349

Query: 358 HKTLGIGILCCSEIVQSVPDAYKKKAISLLASKCSLAARIDYFKKYKEGQYGLLLRQYI 416
             T   G++  S  +       K +    LA+KCS+A+RID + +     +G +L++ +
Sbjct: 350 GNTPKYGLIYHSGFISKASAKNKGRISRYLANKCSMASRIDNYSEEPSNVFGSVLKKQV 408

 Score = 15.4 bits (28), Expect = 5.8
 Identities = 6/16 (37%), Positives = 8/16 (50%)

Query: 535 QGIELYNPSLINAKNK 550
           Q +E YN      KN+
Sbjct: 410 QRLEFYNTGKPTLKNE 425

Lambda     K      H
   0.320    0.136    0.381 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 1
Number of Hits to DB: 440
Number of extensions: 20
Number of successful extensions: 3
Number of sequences better than 10.0: 1
Number of HSP's gapped: 2
Number of HSP's successfully gapped: 2
Length of query: 566
Length of database: 504
Length adjustment: 35
Effective length of query: 531
Effective length of database: 469
Effective search space:   249039
Effective search space used:   249039
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 26 (14.9 bits)
S2: 26 (14.6 bits)