>YOL027C MDM38 SGDID:S000005387, Chr XV from 273725-272004, reverse
           complement, Verified ORF, "Mitochondrial inner membrane
           protein, required for K+/H+ exchange and for normal
           mitochondrial morphology and inheritance; human ortholog
           Letm1 is implicated in Wolf-Hirschhorn syndrome"
          Length = 573

 Score =  118 bits (295), Expect = 1e-30
 Identities = 79/275 (28%), Positives = 135/275 (49%), Gaps = 5/275 (1%)

Query: 318 ENIKKNIKHTIVWVKTGILLFLTNMKISKNLIIKRLKGYRLSYSEYKLLIRTMNDMFKLX 377
           E +   +KH +     G  L    +K+S  L+IK  +GY LS  E   L RTM D+F+L 
Sbjct: 81  ETLMVKVKHALKHYANGTKLLGYEIKVSTKLLIKFAQGYELSRRERNQLRRTMGDVFRLI 140

Query: 378 XXXXXXXXXXAEFLLPIFLKIYPNLLPSTXXXXXXXXXXXXXLY-AKEQLAKFLQQLIEE 436
                     AE  LP  LK++PNLLPST             L   +++ ++FL + +EE
Sbjct: 141 PFSAFLIIPFAELFLPFALKLFPNLLPSTYESGKDKQAKRNKLIEIRKKTSEFLHETLEE 200

Query: 437 KEKQLNENIGIDSEKKKNILNKFHQQLINKDEKDINPFLSVNDTLKIAKIFKEDFVLDQM 496
               +  N   ++EKK+  LN F ++L +  E  I  F   ++   IA++FK D VLD +
Sbjct: 201 -SNLITYNTIENAEKKQKFLN-FFRKLYSAKEGKIMTF-QHDEISAIAQMFKNDSVLDNL 257

Query: 497 NLKTLQTICHLLGLKPYGIHYXXXXXXXXXXXXXXXEDRELIYEGVDNLKHNSLVEICRD 556
           +   L  +   + L+P+G                  +D+ + YEGV++L    L + C  
Sbjct: 258 SRPQLAAMSKFMSLRPFGNDNMLRYQIRSKLKDIMNDDKTIDYEGVESLSQEELYQACVS 317

Query: 557 RGMN-FNTTEKEMKVQIQQWLQLASIKEVPYILLL 590
           RGM  +  +++++   ++ WL+L   +++P +L++
Sbjct: 318 RGMKAYGVSKEDLVDNLKVWLELRLRQKIPSVLMV 352

 Score = 25.0 bits (53), Expect = 0.012
 Identities = 11/38 (28%), Positives = 23/38 (60%)

Query: 663 DDKQKLIQEAKEKLDDLKMKEQEIKKNINKQTDEDDIH 700
           DD +  +   KE+ + +K +E+E K+  +++   DDI+
Sbjct: 509 DDNEFKLNVLKEQEELIKKEEEEAKQRASREHVPDDIN 546

 Score = 21.9 bits (45), Expect = 0.10
 Identities = 13/36 (36%), Positives = 24/36 (66%), Gaps = 5/36 (13%)

Query: 435 EEKEKQLNENIGIDSEKKKNILNKFHQQLINKDEKD 470
           E +EK+ ++    D+E K N+L K  ++LI K+E++
Sbjct: 501 EAEEKKTSD----DNEFKLNVL-KEQEELIKKEEEE 531

 Score = 19.6 bits (39), Expect = 0.50
 Identities = 10/33 (30%), Positives = 16/33 (48%)

Query: 184 KVNQLKEQHNKVNQLKEQHNIEFPATLKPSNIN 216
           K+N LKEQ   + + +E+          P +IN
Sbjct: 514 KLNVLKEQEELIKKEEEEAKQRASREHVPDDIN 546

 Score = 18.9 bits (37), Expect = 0.86
 Identities = 10/44 (22%), Positives = 21/44 (47%)

Query: 164 KVNQLKEQHNKVNQLKEQHNKVNQLKEQHNKVNQLKEQHNIEFP 207
           K+N LKEQ   + + +E+  +    +   + +N  +E+     P
Sbjct: 514 KLNVLKEQEELIKKEEEEAKQRASREHVPDDINLDEEEEAKSVP 557

 Score = 18.5 bits (36), Expect = 1.1
 Identities = 9/53 (16%), Positives = 26/53 (49%)

Query: 176 NQLKEQHNKVNQLKEQHNKVNQLKEQHNIEFPATLKPSNINNKKGVYHEEREE 228
           N L   +      + + NK+ +++++ +     TL+ SN+     + + E+++
Sbjct: 164 NLLPSTYESGKDKQAKRNKLIEIRKKTSEFLHETLEESNLITYNTIENAEKKQ 216

 Score = 17.7 bits (34), Expect = 1.9
 Identities = 8/27 (29%), Positives = 16/27 (59%), Gaps = 6/27 (22%)

Query: 670 QEAKEKL------DDLKMKEQEIKKNI 690
           +EAK++       DD+ + E+E  K++
Sbjct: 530 EEAKQRASREHVPDDINLDEEEEAKSV 556

 Score = 17.3 bits (33), Expect = 2.5
 Identities = 11/48 (22%), Positives = 22/48 (45%)

Query: 159 KEEHNKVNQLKEQHNKVNQLKEQHNKVNQLKEQHNKVNQLKEQHNIEF 206
           K++  K N+L E   K ++   +  + + L   +   N  K+Q  + F
Sbjct: 174 KDKQAKRNKLIEIRKKTSEFLHETLEESNLITYNTIENAEKKQKFLNF 221

 Score = 15.8 bits (29), Expect = 7.2
 Identities = 6/12 (50%), Positives = 7/12 (58%)

Query: 790 EDKKTDDSLNVK 801
           E+KKT D    K
Sbjct: 503 EEKKTSDDNEFK 514

 Score = 15.4 bits (28), Expect = 9.5
 Identities = 5/12 (41%), Positives = 6/12 (50%)

Query: 18  YYGCVKRTFYSY 29
           Y  CV R   +Y
Sbjct: 312 YQACVSRGMKAY 323

Lambda     K      H
   0.316    0.134    0.377 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 1
Number of Hits to DB: 968
Number of extensions: 53
Number of successful extensions: 19
Number of sequences better than 10.0: 1
Number of HSP's gapped: 10
Number of HSP's successfully gapped: 10
Length of query: 802
Length of database: 573
Length adjustment: 39
Effective length of query: 763
Effective length of database: 534
Effective search space:   407442
Effective search space used:   407442
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)