>YLR274W CDC46 SGDID:S000004264, Chr XII from 691557-693884,
           Verified ORF, "Component of the hexameric MCM complex,
           which is important for priming origins of DNA
           replication in G1 and becomes an active ATP-dependent
           helicase that promotes DNA melting and elongation when
           activated by Cdc7p-Dbf4p in S-phase"
          Length = 775

 Score =  445 bits (1144), Expect = e-129
 Identities = 285/732 (38%), Positives = 410/732 (56%), Gaps = 51/732 (6%)

Query: 70  NFTLDLKLDDIYKQQTVFENNEISATPRSERKMKKPENYSAILARALSERPLTYLPTIER 129
           NF L+ +LD  +  +    NN +         M+    Y+  + + LS+ P   +P  E 
Sbjct: 33  NFILEFRLDSQFIYRDQLRNNILVKNYSLTVNMEHLIGYNEDIYKKLSDEPSDIIPLFET 92

Query: 130 VCYEVCETANIL--------NDEDEHLNYIQIN------------LLNTFIRPTPIRGLL 169
              +V +  +IL        ND+D     +  +            +LN+     P+R L 
Sbjct: 93  AITQVAKRISILSRAQSANNNDKDPENTSMDTDSLLLNSLPTFQLILNSNANQIPLRDLD 152

Query: 170 AATQERFVVVPGIIVQASKPQHKMRKITLQCRYCDHKMSIDV----PLWRDKPQLPPYCR 225
           +    + V + GII+  S    +   +++ CR C H  SI +     +  +   LP  C 
Sbjct: 153 SEHVSKIVRLSGIIISTSVLSSRATYLSIMCRNCRHTTSITINNFNSITGNTVSLPRSCL 212

Query: 226 YSSTMKSSMGL-GNAMDSQLGCNGVLEPYVILPNECTFVDIQSLKMQELPEAVPTGDMPR 284
            +   +SSM    N  D     N   +PY+I+     F+D Q LK+QE+PE VP G+MPR
Sbjct: 213 STIESESSMANESNIGDESTKKNCGPDPYIIIHESSKFIDQQFLKLQEIPELVPVGEMPR 272

Query: 285 HLQLNVTRYLCEKMIPGDRVYVHGVLTSYNPN--PRPTRADGTNFS--------YLHVLG 334
           +L +   RYL  K+IPG RV + G+ + YN        R+ G N          Y+ +LG
Sbjct: 273 NLTMTCDRYLTNKVIPGTRVTIVGIYSIYNSKNGAGSGRSGGGNGGSGVAIRTPYIKILG 332

Query: 335 FQKYDDMSG--NDLN-FDVEERNELTLLAAEHNIHEKIFKSIAPELYGMDEVKKACACLL 391
            Q   + S   N +  F  EE  E   L+    ++E +  SIAP ++G +++KKA  CLL
Sbjct: 333 IQSDVETSSIWNSVTMFTEEEEEEFLQLSRNPKLYEILTNSIAPSIFGNEDIKKAIVCLL 392

Query: 392 FGGTRKRIGEETKIRGDINMLMLGDPSVAKSQILKFVNRCAPVSVYTSGKGSSAAGLTAA 451
            GG++K + +  ++RGDIN+L+LGDP  AKSQ+LKFV + +P++VYTSGKGSSAAGLTA+
Sbjct: 393 MGGSKKILPDGMRLRGDINVLLLGDPGTAKSQLLKFVEKVSPIAVYTSGKGSSAAGLTAS 452

Query: 452 VMRDSQG-VFSLEGGAMVLADGGVVCIDEFDKMRDDDVVAIHEAMEQQTISISKAGITTM 510
           V RD     F LEGGAMVLADGGVVCIDEFDKMRD+D VAIHEAMEQQTISI+KAGITT+
Sbjct: 453 VQRDPMTREFYLEGGAMVLADGGVVCIDEFDKMRDEDRVAIHEAMEQQTISIAKAGITTV 512

Query: 511 LNTRCSVIAAANPSFGSYDDSQDTTYQHDFKTTILSRFDIIFLLRNKQDVEKDTLLCNHI 570
           LN+R SV+AAANP +G YDD +      DF+TTILSRFD+IF++++  + E+D  + NH+
Sbjct: 513 LNSRTSVLAAANPIYGRYDDLKSPGDNIDFQTTILSRFDMIFIVKDDHNEERDISIANHV 572

Query: 571 VALH-----ASKHKSQE--GEIPLSKLTRYIQYAKREIAPLLSKEARDSLRNFYVQTRAE 623
           + +H     A +++ +E   EI + K+ RYI Y + + AP LS +A + L + +V  R +
Sbjct: 573 INIHTGNANAMQNQQEENGSEISIEKMKRYITYCRLKCAPRLSPQAAEKLSSNFVTIRKQ 632

Query: 624 YRGDRRSVTKK--IPITLRQLESLIRLAESFAKMELSQFATDKHVQMSIDLFSASTAETA 681
              +    T++  IPIT+RQLE++IR+ ES AK+ELS  A ++HV  +I LF AST + A
Sbjct: 633 LLINELESTERSSIPITIRQLEAIIRITESLAKLELSPIAQERHVDEAIRLFQASTMDAA 692

Query: 682 KQCLI--FETMSPLEQKAVKQAEDAILGRLGKGQRASRVNLFRE-LQLRGFDRSALSKAL 738
            Q  I      S      +++ E  +  RL  G   S   L RE +    F + AL KAL
Sbjct: 693 SQDPIGGLNQASGTSLSEIRRFEQELKRRLPIGWSTSYQTLRREFVDTHRFSQLALDKAL 752

Query: 739 AILIKKGELQER 750
             L K   +Q R
Sbjct: 753 YALEKHETIQLR 764

Lambda     K      H
   0.319    0.135    0.385 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 1
Number of Hits to DB: 1226
Number of extensions: 53
Number of successful extensions: 8
Number of sequences better than 10.0: 1
Number of HSP's gapped: 1
Number of HSP's successfully gapped: 1
Length of query: 758
Length of database: 775
Length adjustment: 41
Effective length of query: 717
Effective length of database: 734
Effective search space:   526278
Effective search space used:   526278
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 29 (16.3 bits)
S2: 29 (15.8 bits)