>YDR211W GCD6 SGDID:S000002619, Chr IV from 884723-886861, Verified
           ORF, "Catalytic epsilon subunit of the translation
           initiation factor eIF2B, the guanine-nucleotide exchange
           factor for eIF2; activity subsequently regulated by
           phosphorylated eIF2; first identified as a negative
           regulator of GCN4 expression"
          Length = 712

 Score = 95.5 bits (236), Expect = 1e-23
 Identities = 80/369 (21%), Positives = 166/369 (44%), Gaps = 14/369 (3%)

Query: 369 NSIIISYDLIIPNIFIITPQVLKLFEDNFDYQCIKKDFIYNILKQEIKIEEIYVHEINGD 428
           +  +I  DLI   I I T  V  +F++NFDYQ ++ DF+  ++  +I  + IY +  +  
Sbjct: 222 DEFVIRNDLIDCRIDICTSHVPLIFQENFDYQSLRTDFVKGVISSDILGKHIYAYLTDEY 281

Query: 429 YNYTECNNIITTLSDFRIYFKFFKMLIERNVHPFLANAYHLLPEQPKRVLTEPGFYKHKN 488
               E      T+S   +    + ++++ N+      +Y                YK K+
Sbjct: 282 AVRVESWQTYDTISQDFLGRWCYPLVLDSNIQDDQTYSYE-----------SRHIYKEKD 330

Query: 489 AIVHDTCKLYKIVLVEKFSEILDNSTIENSVXXXXXXXXXXXXXXXTVIANNCIIKDNVS 548
            ++  +CK+ K   +   ++I + + IENSV               + I ++CII +N  
Sbjct: 331 VVLAQSCKIGKCTAIGSGTKIGEGTKIENSVIGRNCQIGENIRIKNSFIWDDCIIGNNSI 390

Query: 549 ILSSFIYENVIINENVFIDECCVLGKNINIPCNIEIPKYTRLSAYYTNNVKDKLQLEKKN 608
           I  S I  N  +  NV +++ C++G N+ I  N+++ + T++SA    N   ++   + N
Sbjct: 391 IDHSLIASNATLGSNVRLNDGCIIGFNVKIDDNMDLDRNTKISASPLKNAGSRMYDNESN 450

Query: 609 KEEDILLEEHRKVREIEESQNDITNVKEEDTIDNQD-TFENEKEVSDIICHQHMQREEND 667
           ++ D  L++      I      +  + E +  D++D + E  KE++ +          +D
Sbjct: 451 EQFDQDLDDQTLAVSI-VGDKGVGYIYESEVSDDEDSSTEACKEINTLSNQLDELYLSDD 509

Query: 668 YVIIDEKSFDNPKEVANSNILNDQENIKREDKEYVILDQAHAHLNASIDNEM-LDHKVDE 726
            +    K     + ++ ++I  D+E I  E ++     +  A +  +++N   LD  + E
Sbjct: 510 SISSATKKTKKRRTMSVNSIYTDREEIDSEFEDEDFEKEGIATVERAMENNHDLDTALLE 569

Query: 727 KHTDKINAN 735
            +T +++ N
Sbjct: 570 LNTLRMSMN 578

 Score = 48.9 bits (115), Expect = 1e-09
 Identities = 30/121 (24%), Positives = 60/121 (49%), Gaps = 2/121 (1%)

Query: 6   LIDYQLHFFKQNNVKKIYVVVTHHENELLDYIEKFQRSKKRYNDLDIEIIKMNKKVKTLG 65
           LI+Y L F  +  V +++++ + H N++ DYIE   +    ++   I  I M+ + +  G
Sbjct: 59  LIEYTLEFLAKAGVHEVFLICSSHANQINDYIEN-SKWNLPWSPFKITTI-MSPEARCTG 116

Query: 66  DALRDFKKSVEVYNDILLLLSDTIPIANVKDIIKAHFTNKEKCKNQIMTLILSHCSSENK 125
           D +RD      +  D +L+  D +   +   +++ H     + K+ I T+ LS  S+  K
Sbjct: 117 DVMRDLDNRGIITGDFILVSGDVLTNIDFSKMLEFHKKMHLQDKDHISTMCLSKASTYPK 176

Query: 126 S 126
           +
Sbjct: 177 T 177

 Score = 30.4 bits (67), Expect = 5e-04
 Identities = 41/193 (21%), Positives = 90/193 (46%), Gaps = 18/193 (9%)

Query: 909  SVNMSDINKHFNDINMDNEKNIFSKEISLLCKEAINKPQFMSHKILEMKSFRLSLNYTDL 968
            +++++ I     +I+ + E   F KE     + A+     +   +LE+ + R+S+N T  
Sbjct: 523  TMSVNSIYTDREEIDSEFEDEDFEKEGIATVERAMENNHDLDTALLELNTLRMSMNVTYH 582

Query: 969  DV----LVGIFPIIWEYI-NQLPFDKESWIENFDNAKLDMLFSSFLLEDQCYYETLYDLI 1023
            +V    +  +   ++ +I  Q    K++ ++ F+  +  +LF     +++ Y + L ++I
Sbjct: 583  EVRIATITALLRRVYHFIATQTLGPKDAVVKVFN--QWGLLFKRQAFDEEEYID-LMNII 639

Query: 1024 LDYSKKQYLTSNIKNNIFGSDKLCNAFEYIYHSDIFEFNYFNEWINKNQSDEFLKNNMRL 1083
            ++   +Q   S  K ++     L +A   +Y +DI E +   +W +   +D       +L
Sbjct: 640  MEKIVEQ---SFDKPDLI----LFSALVSLYDNDIIEEDVIYKWWDNVSTDPRYDEVKKL 692

Query: 1084 KA-FAEWL--ADE 1093
               + EWL  ADE
Sbjct: 693  TVKWVEWLQNADE 705

 Score = 19.6 bits (39), Expect = 0.87
 Identities = 9/26 (34%), Positives = 16/26 (61%), Gaps = 2/26 (7%)

Query: 163 DINIKDRKGCRYEEKGLFKGGNKDLI 188
           D NI+D +   YE + ++K   KD++
Sbjct: 309 DSNIQDDQTYSYESRHIYK--EKDVV 332

 Score = 18.5 bits (36), Expect = 1.9
 Identities = 12/32 (37%), Positives = 18/32 (56%), Gaps = 1/32 (3%)

Query: 671 IDEKSFDNPKEVANSNILNDQEN-IKREDKEY 701
           I E+SFD P  +  S +++  +N I  ED  Y
Sbjct: 643 IVEQSFDKPDLILFSALVSLYDNDIIEEDVIY 674

 Score = 17.3 bits (33), Expect = 4.3
 Identities = 16/67 (23%), Positives = 26/67 (38%), Gaps = 15/67 (22%)

Query: 731 KINANQDFICGDKELPSVLSDKNEEQNNNFVHVVNDIENNEGIDQNTEKNNNISVDENIS 790
           KI+ N D     K   S L +      +N        E+NE  DQ+ +       D+ ++
Sbjct: 419 KIDDNMDLDRNTKISASPLKNAGSRMYDN--------ESNEQFDQDLD-------DQTLA 463

Query: 791 IGIKPSK 797
           + I   K
Sbjct: 464 VSIVGDK 470

Lambda     K      H
   0.318    0.137    0.399 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 1
Number of Hits to DB: 2014
Number of extensions: 128
Number of successful extensions: 13
Number of sequences better than 10.0: 1
Number of HSP's gapped: 7
Number of HSP's successfully gapped: 7
Length of query: 1093
Length of database: 712
Length adjustment: 43
Effective length of query: 1050
Effective length of database: 669
Effective search space:   702450
Effective search space used:   702450
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 30 (16.6 bits)
S2: 30 (16.2 bits)