>YPR112C MRD1 SGDID:S000006316, Chr XVI from 751917-749254, reverse
            complement, Verified ORF, "Essential conserved protein
            that associates with 35S precursor rRNA and is required
            for its initial processing at the A(0)-A(2) cleavage
            sites, shows partial nucleolar localization, contains
            five consensus RNA-binding domains"
          Length = 887

 Score =  180 bits (457), Expect = 4e-49
 Identities = 139/597 (23%), Positives = 255/597 (42%), Gaps = 121/597 (20%)

Query: 497  YAFVNFMFPSSCEKAKIHLDNKIYRGKILIAKYSXXXXXXXXXXXXXXXXXXXXXXXLSN 556
            +A+V F    +   A + LD +I++G++L                            L N
Sbjct: 388  FAYVLFKDSKNAVNAYVELDKQIFQGRLL-----------HILPGEEKKSHRLDEFDLKN 436

Query: 557  DCKTSYKKIVEIQKKKSCQNENM-WNILYTDINTSINNFCKENNCSVESVLNIKDKNIAV 615
                  KK  E+++K +   +   WN LY + +  + +   +       +++ ++ + AV
Sbjct: 437  ---MPLKKQKELKRKAAASRQTFSWNSLYMNQDAVLGSVAAKLGLEKSQLIDAENSSSAV 493

Query: 616  NVSLTETYIINKIKTWIKNEGIYLDAFEQIYVKKKKNEDEKDXXXXXXXXXXXXXXXXXX 675
              +L E ++I  ++ + +++G+ L  F Q+   K  N+                      
Sbjct: 494  KQALAEAHVIGDVRKYFESKGVDLTKFSQL---KSTNQ---------------------- 528

Query: 676  XXXXXXXXXXXXVDKDDKEIVKYRRSDDTIIIKNLSIYTNQNDIINLFKQYGILKRVSFS 735
                                    R D  I++KN    T + ++  +F  YG L+R+   
Sbjct: 529  ------------------------RDDKVILVKNFPFGTTREELGEMFLPYGKLERLLMP 564

Query: 736  PYNNICIIQYENADNAKKAFISNSYIRYKKLPLYLEWAPLNLFAKQKDIED--DNNYGMN 793
            P   I I+Q+ +  +A+ AF   SY R+K   +YLE  P + F K  + +D  +N     
Sbjct: 565  PAGTIAIVQFRDTTSARAAFTKLSYKRFKDGIIYLERGPKDCFTKPAEADDLINNTSAKE 624

Query: 794  DKRTIKREETNEDDVTRNTDQYDHKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 853
            ++  ++ + ++ D +  N D  +                                     
Sbjct: 625  EENPVEVKPSSNDLMEANKDVTEGSSNAHDEDVI-------------------------- 658

Query: 854  EYGEGTHASIYIKNINFNTKEEDLKNLFDKMEGFITCNIVKSKKVILQKDKESNKISNQY 913
               +G   SI+IKN+NF+T  ++L + F    GF+   +         K K   K  +Q 
Sbjct: 659  ---DGPTVSIFIKNLNFSTTNQNLTDRFKVFTGFVVAQV---------KTKPDPK--HQG 704

Query: 914  NTVSSGYGFAEFKNKELAMEAIKRLTGTRLNDHLLEMSLSHXXXXXXXXXXXXXXEDEKL 973
             T+S G+GF EF+ KE A   I  + GT ++ H +++ LSH                   
Sbjct: 705  KTLSMGFGFVEFRTKEQANAVIAAMDGTVIDGHKIQLKLSHRQASQ---------SGNTK 755

Query: 974  VLKNKKQVTKKLVVKNLAFQVNKEELRKLFSAFGNVKSVRIPKNVYNRSRGYAFIEFMSK 1033
               NKK  + K++VKNL F+  ++++ +LF++FG +KSVR+PK     +RG+AF+EF+  
Sbjct: 756  TKSNKK--SGKIIVKNLPFEATRKDVFELFNSFGQLKSVRVPKKFDKSARGFAFVEFLLP 813

Query: 1034 KESCNAIESLQHTHLYGRHLIIDFADDFMFDKNVDEYDKLKELNNQQNKDIITSEQA 1090
            KE+ NA++ L   HL GR L++ +A+    +  VD  +++  +  +  K + T+E A
Sbjct: 814  KEAENAMDQLHGVHLLGRRLVMQYAE----EDAVDAEEEIARMTKKVRKQVATNEMA 866

 Score = 52.8 bits (125), Expect = 1e-10
 Identities = 36/126 (28%), Positives = 66/126 (52%), Gaps = 4/126 (3%)

Query: 970  DEKLVLKNKKQVTKKLVVKNLAFQVNKEELRKLFSAFGNVKSVRIPKNV-YNRSRGYAFI 1028
            DE+L ++   Q T +L ++N+ +   +E+ RKLFS FG ++ V +  +    +S+G+A++
Sbjct: 333  DEELAIEKINQ-TGRLFLRNILYTSKEEDFRKLFSPFGELEEVHVALDTRTGQSKGFAYV 391

Query: 1029 EFMSKKESCNAIESLQHTHLYGRHLIIDFADDFMFDKNVDEYDKLKELNNQQNKDIITSE 1088
             F   K + NA   L      GR L I    +      +DE+D LK +  ++ K++    
Sbjct: 392  LFKDSKNAVNAYVELDKQIFQGRLLHI-LPGEEKKSHRLDEFD-LKNMPLKKQKELKRKA 449

Query: 1089 QAKRKS 1094
             A R++
Sbjct: 450  AASRQT 455

 Score = 46.6 bits (109), Expect = 9e-09
 Identities = 29/96 (30%), Positives = 48/96 (50%), Gaps = 2/96 (2%)

Query: 45  TRLIIKNIPKYMNEIDLKKHFFKM--KDHNINFQXXXXXXXXXXXXXXXXEHYESRRICF 102
           +R+I+K +P Y+ + +L++HF K   + H+                     + ESRR  F
Sbjct: 2   SRIIVKGLPVYLTDDNLREHFTKRLRQKHSHQAVNGSGPDLITDVKILRDRNGESRRFGF 61

Query: 103 IGFLNNYHCQCFKKFFNNTYINTSKIIIEDAISPSD 138
           IG+ N        ++FN ++INTSKI +  A S +D
Sbjct: 62  IGYRNEEDAFDAVEYFNGSFINTSKIEVSMAKSFAD 97

 Score = 30.8 bits (68), Expect = 5e-04
 Identities = 14/46 (30%), Positives = 27/46 (58%)

Query: 908 KISNQYNTVSSGYGFAEFKNKELAMEAIKRLTGTRLNDHLLEMSLS 953
           KI    N  S  +GF  ++N+E A +A++   G+ +N   +E+S++
Sbjct: 47  KILRDRNGESRRFGFIGYRNEEDAFDAVEYFNGSFINTSKIEVSMA 92

 Score = 27.3 bits (59), Expect = 0.005
 Identities = 43/227 (18%), Positives = 89/227 (39%), Gaps = 42/227 (18%)

Query: 863  IYIKNINFNTKEEDLKNLFDKMEGFITCNIVKSKKVILQKDKESNKISNQYNTVSSGYGF 922
            ++++NI + +KEED + LF            + ++V +  D  + +        S G+ +
Sbjct: 347  LFLRNILYTSKEEDFRKLFSPFG--------ELEEVHVALDTRTGQ--------SKGFAY 390

Query: 923  AEFKNKELAMEAIKRLTGTRLNDHLLEMSLSHXXXXXXXXXXXXXXEDEK-LVLKNKKQV 981
              FK+ + A+ A        L+  + +  L H               D K + LK +K++
Sbjct: 391  VLFKDSKNAVNAY-----VELDKQIFQGRLLHILPGEEKKSHRLDEFDLKNMPLKKQKEL 445

Query: 982  TKKLVVKNLAFQVNKEELRKLFSAFGNVKSVRIPKNVYNRSRGYAFIEFMSKKESCNAI- 1040
             +K       F  N   + +  +  G+V +            G    + +  + S +A+ 
Sbjct: 446  KRKAAASRQTFSWNSLYMNQ-DAVLGSVAA----------KLGLEKSQLIDAENSSSAVK 494

Query: 1041 ESLQHTHLYGRHLIIDFADDFMFDKNVD--EYDKLKELNNQQNKDII 1085
            ++L   H+ G          +   K VD  ++ +LK  N + +K I+
Sbjct: 495  QALAEAHVIGD------VRKYFESKGVDLTKFSQLKSTNQRDDKVIL 535

 Score = 25.0 bits (53), Expect = 0.027
 Identities = 13/36 (36%), Positives = 21/36 (58%), Gaps = 1/36 (2%)

Query: 375 TGKLIIFNLP-PINEQDIKSLCERYGPIVDVKVFKK 409
           +GK+I+ NLP     +D+  L   +G +  V+V KK
Sbjct: 762 SGKIIVKNLPFEATRKDVFELFNSFGQLKSVRVPKK 797

 Score = 18.5 bits (36), Expect = 2.5
 Identities = 8/22 (36%), Positives = 12/22 (54%)

Query: 793 NDKRTIKREETNEDDVTRNTDQ 814
           N+    K+EE  E  V + TD+
Sbjct: 313 NESLDTKKEEQPERAVPQKTDE 334

 Score = 17.3 bits (33), Expect = 5.5
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 36 KNEEDGYD 43
          +NEED +D
Sbjct: 65 RNEEDAFD 72

 Score = 17.3 bits (33), Expect = 5.5
 Identities = 7/23 (30%), Positives = 14/23 (60%), Gaps = 4/23 (17%)

Query: 31  NLFSSKNEEDGYDKTRLIIKNIP 53
           N  +  N++ G    ++I+KN+P
Sbjct: 753 NTKTKSNKKSG----KIIVKNLP 771

 Score = 16.5 bits (31), Expect = 9.4
 Identities = 6/16 (37%), Positives = 10/16 (62%)

Query: 296 DDASNTHSNNEDNALE 311
           D  +NT +  E+N +E
Sbjct: 615 DLINNTSAKEEENPVE 630

Lambda     K      H
   0.315    0.131    0.372 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 1
Number of Hits to DB: 2214
Number of extensions: 124
Number of successful extensions: 18
Number of sequences better than 10.0: 1
Number of HSP's gapped: 14
Number of HSP's successfully gapped: 14
Length of query: 1119
Length of database: 887
Length adjustment: 44
Effective length of query: 1075
Effective length of database: 843
Effective search space:   906225
Effective search space used:   906225
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 31 (17.0 bits)
S2: 31 (16.5 bits)