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border="0" width="100%"> <tr> <td height="10"><img height="10" src="/images/dot.gif"></td> </tr> <tr> <td width="10"><img src="/images/dot.gif" width="10"></td><td> <!----> <table cellspacing="0" cellpadding="0" border="0" width="100%"> <tr> <td><span class="pageTitle">C&eacute;line&nbsp;Boudreau-Larivi&egrave;re</span> <br> <img src="/images/blue.gif" width="560" height="1"></td> </tr> <tr> <td height="10"><img height="10" src="/images/dot.gif"></td> </tr> <tr> <td> <table align="left" cellspacing="0" cellpadding="0" border="0"> <tr> <td colspan="5" height="8"><img height="8" src="/images/dot.gif"></td> </tr> <tr> <td width="8" height="1"><img width="8" src="/images/dot.gif" height="1"></td><td height="1" bgcolor="#000000" colspan="3"><img src="/images/dot.gif" height="1"></td><td height="1" width="8"><img height="1" width="8" src="/images/dot.gif"></td> </tr> <tr> <td width="8"><img width="8" src="/images/dot.gif"></td><td width="1" bgcolor="#000000"><img src="/images/dot.gif" width="1"></td><td><img border="0" src="http://209.91.162.35/FeedStream/Content/Celine%28HK%29.JPG"></td><td width="1" bgcolor="#000000"><img src="/images/dot.gif" width="1"></td><td width="8"><img width="8" src="/images/dot.gif"></td> </tr> <tr> <td width="8" height="1"><img width="8" src="/images/dot.gif" height="1"></td><td height="1" bgcolor="#000000" colspan="3"><img src="/images/dot.gif" height="1"></td><td height="1" width="8"><img height="1" width="8" src="/images/dot.gif"></td> </tr> <tr> <td colspan="5" height="8"><img height="8" src="/images/dot.gif"></td> </tr> </table> <span class="subPageTitle">Professeure adjointe,&nbsp;B.P.H.E., M.Sc., Ph.D. <br>B.E.P.S., M.Sc. Universit&eacute; Laurentienne, Ph.D. Universit&eacute; d'Ottawa</span> <br> <span class="pageBody"> 				T&eacute;l: (705) 675-1151&nbsp;&nbsp;Ext:1003<br> 				T&eacute;l&eacute;copieur: 675-4845<br> 				Courriel: 				<span class="langLink"><a class="langLink2" href="mailto:cboudreaulariviere@laurentian.ca">cboudreaulariviere@laurentian.ca</a></span> <br> 				Disponibilit&eacute;:<br>lundi au vendredi 8h30 &agrave; 16h30<br> <br> </span></td> </tr> <tr> <td><span class="subPageTitle">Recherche</span> <br> <span class="pageBody">  <br>  <div align="left">J'ai un int&eacute;r&ecirc;t de longue date pour la recherche li&eacute;e aux m&eacute;canismes cellulaires et mol&eacute;culaires r&eacute;gissant le ph&eacute;notype des fibres musculaires squelettiques et de la plasticit&eacute; de ces &eacute;v&eacute;nements pendant le d&eacute;veloppement du muscle.  Pendant ma formation de 2&egrave;me cycle, j'ai examin&eacute; les caract&eacute;ristiques fonctionnelles des unit&eacute;s motrices chez le rat aussi bien que l'impact de l'activit&eacute; &eacute;lectrique du motoneurone sur les propri&eacute;t&eacute;s contractiles et m&eacute;taboliques des fibres rapides et lentes de muscle squelettique.  En outre, j'ai &eacute;tudi&eacute; les m&eacute;canismes r&eacute;gissant l'assemblage, l'entretien et la plasticit&eacute; de la jonction neuromusculaire.  Ces &eacute;tudes avaient pour objectif de faire une mise au point des &eacute;v&eacute;nements cellulaires et mol&eacute;culaires gouvernant l&rsquo;expression du g&egrave;ne de l'acetylcholinesterase du c&ocirc;t&eacute; post-synaptique de la jonction neuromusculaire.  Plus r&eacute;cemment, j'ai &eacute;largi mon champs d&rsquo;int&eacute;r&ecirc;t pour y inclure les composantes cytosquelettiques du muscle.  Ces divers &eacute;l&eacute;ments du cytosquelette et en particulier, les prot&eacute;ines appartenant &agrave; la famille des &ldquo;plakins&rdquo;, jouent un r&ocirc;le important dans l'&eacute;tablissement et l'entretien de l'int&eacute;grit&eacute; structurale des cellules de muscle.  Puisque la fonction pr&eacute;cise de ces prot&eacute;ines n&rsquo;a pas &eacute;t&eacute; &eacute;labor&eacute;e, mon programme de recherche vise donc de d&eacute;finir l&rsquo;importance des prot&eacute;ines cytosquelettiques dans certains processus physiologiques du muscle squelettique.  </div> </span></td> </tr> <tr> <td height="10"><img height="10" src="/images/dot.gif"></td> </tr> <tr> <td><span class="subPageTitle">Publications</span> <br> <span class="pageBody">  <br>  <div align="left"> <span style="font-weight:800">Contributions (10 derni&egrave;res ann&eacute;es)</span> </div>  <br>  <div align="left"> <u><i><span style="font-weight:800">a) Publications avec comit&eacute; de lecture</span></i></u> </div>  <br>  <div align="left">1) <span style="font-weight:800">Boudreau-Larivi&egrave;re, C.</span> and Kothary, R. 2002. Differentiation potential of primary myogenic cells derived from skeletal muscle of dystonia musculorum mice.  <i>Differentiation</i>, 70: 247-256.</div>  <br>  <div align="left">2) <span style="font-weight:800">Boudreau-Larivi&egrave;re, C.</span>, Chan, R.Y.Y., and Jasmin, B.J.  2000. Molecular mechanisms underlying the activity-linked alterations in acetylcholinesterase mRNAs in developing versus adult rat skeletal muscles, <i>J. Neurochem.</i>, 74:2250-2258.</div>  <br>  <div align="left">3) <span style="font-weight:800">Boudreau-Larivi&egrave;re, C.</span>, Parry, D.J., and Jasmin, B.J.  2000. Myotubes originating from single fast and slow satellite cells display similar patterns of AChE expression.  <i>Am. J. Physiol. (Reg. Int. Comp. Physiol.)</i>, 278:R140-R148.</div>  <br>  <div align="left">4) Chan, R.Y.Y., <span style="font-weight:800">Boudreau-Larivi&egrave;re, C.</span>, Angus, L., Mankal, F.A., and Jasmin, B.J. 1999. An intronic enhancer containing an N-box motif is required for synapse- and tissue-specific expression of the acetylcholinesterase gene in skeletal muscle fibers. <i>Proc. Natl. Acad. Sci. USA</i>, 96:4627-4632.</div>  <br>  <div align="left">5) <span style="font-weight:800">Boudreau-Larivi&egrave;re, C.</span> and Jasmin, B. J. 1999. CGRP decreases expression of acetylcholinesterase in mammalian myotubes. <i>FEBS Lett.</i>, 444:22-26.</div>  <br>  <div align="left">6) <span style="font-weight:800">Boudreau-Larivi&egrave;re, C.</span>, Gisiger, V., Michel, R.N., Hubatsch, D. A., and  Jasmin, B .J.  1997.  Fast and slow skeletal muscle express a common basic profile of acetylcholinesterase molecular forms. <i>Am. J. Physiol. (Cell Physiol.)</i>, 272:C68-C76.</div>  <br>  <div align="left">7) <span style="font-weight:800">Boudreau-Larivi&egrave;re, C.</span>, Sveistrup, H., Parry, D., and Jasmin, B. J.  1996. Ciliary neurotrophic factor:  regulation of acetylcholinesterase in rat skeletal muscle and distribution of messenger RNA encoding its receptor in synaptic versus extrasynaptic compartments. <i>Neurosci.</i>, 73: 613-622.</div>  <br>  <br>  <div align="left"> <u><i><span style="font-weight:800">b) Autres publications avec comit&eacute; de lecture</span></i></u> </div>  <br>  <div align="left">1)  <span style="font-weight:800">Boudreau-Larivi&egrave;re, C.</span>, Pool, M., De Repentigny, Y. and Kothary, R. 2001. Novel insights into the molecular organization of the dystonia musculorum locus.  <i>Soc. for Neurosci.</i>, 27:983.8.</div>  <br>  <div align="left">2) <span style="font-weight:800">Boudreau-Larivi&egrave;re, C.</span>, Chan, R.Y.Y., and Jasmin, B.J.  1998.  Activity-linked regulation of acetylcholinesterase mRNA levels involves distinct molecular mechanisms in developing versus adult skeletal muscle.  <i>Sixth International Conference on Cholinesterases and Related Proteins</i>, p. 128.</div>  <br>  <div align="left">3) Chan, R.Y.Y., <span style="font-weight:800">Boudreau-Larivi&egrave;re, C.</span>, Mankal, F.A., Angus, L., Krupa, A. M. and Jasmin, B.J.  1998.  Expression of the acetylcholinesterase gene in skeletal muscle fibers:  role of intronic sequences.  <i>Sixth International Conference on Cholinesterases and Related Proteins</i>, p. 119.</div>  <br>  <div align="left">4) Jasmin, B.J., Chan, R.Y.Y., <span style="font-weight:800">Boudreau-Larivi&egrave;re, C.</span>, Angus, L., Mankal, F.A., and Krupa, A. M.  1998. Molecular mechanisms underlying the synapse-specific expression and activity-linked regulation of acetylcholinesterase at the neuromuscular junction: role of intronic sequences.  <i>J. Physiol. (Paris)</i>, 92: 442.</div>  <br>  <div align="left">5) Jasmin, B.J., Gramolini, A.O., Adatia, F.A., Angus, L., <span style="font-weight:800">Boudreau-Larivi&egrave;re, C.</span>, Chan, R.Y.Y., Krupa, A.M., Lunde, J.A., Mankal, F.A., Wu, J. 1998. Nerve-derived trophic factors and DNA elements controlling expression of genes encoding synaptic proteins in skeletal muscle fibers. <i>Can. J. Appl. Physiol.</i> 23:366-376.</div>  <br>  <div align="left">6) <span style="font-weight:800">Boudreau-Larivi&egrave;re, C.</span> and Jasmin, B.J.  1997. Trophic regulation of acetylcholinesterase expression in cultured mouse myotubes. <i>Soc. for Neurosci.</i>, 23: 32. </div>  <br>  <div align="left">7)  <span style="font-weight:800">Boudreau-Larivi&egrave;re, C.</span> and Jasmin, B.J. 1996.  Rapid induction of G4 acetylcholinesterase following high-frequency nerve-derived electrical stimulation of inactivated muscles.  <i>The Physiologist</i>, 39(5): A-72.</div>  <br>  <div align="left">8) <span style="font-weight:800">Boudreau-Larivi&egrave;re, C.</span>, Chan, R.Y.Y., Mankal, F.A., and Jasmin, B.J.  1996.  Innervation-independent transcriptional regulation of the acetylcholinesterase gene in adult skeletal muscle fibers.  <i>Soc. for Neurosci.</i>, 22: 1100.</div>  <br>  <div align="left">9) <span style="font-weight:800">Boudreau-Larivi&egrave;re, C.</span> and Jasmin, B.J.  1995.  Differential regulation of acetylcholinesterase in slow and fast muscles by nerve-mediated electrical activation. <i>Mol. Biol. Cell</i>,6:250a.</div>  <br>  <div align="left">10) <span style="font-weight:800">Boudreau-Larivi&egrave;re, C.</span>, Gisiger, V., Hubatsch, D.A., and Jasmin, B.J.  1995.  Fast and slow muscles express a common basic pattern of acetylcholinesterase molecular forms. <i>Soc. for Neurosci.</i> 21:799.</div>  <br>  <div align="left">11) <span style="font-weight:800">Boudreau-Larivi&egrave;re, C.</span> and Michel, R.N.  1994.  Rat plantaris motor unit characteristics after prolonged tetrodotoxin-induced paralysis and periodic short-term neural activation.  <i>Can. J. App. Physiol.</i> 19, supplement: 7P.</div>  <br>  <div align="left">12) <span style="font-weight:800">Boudreau, C.</span> and Michel, R.N.  1993.  Counteraction of the short-term effects of complete disuse of rat plantaris by sciatic nerve stimulation. <i>Can. J. App. Physiol.</i> 18:400P.</div>  <br>  <div align="left">13) Megeney, L., Michel, R., <span style="font-weight:800">Boudreau, C.</span>, Tan, M., Prasad, M. and Bonen, A.  1993. Comparison of denervation and tetrodotoxin (TTX) on GLUT4 expression in rat hindlimb muscles. <i>Can. J. App. Physiol.</i> 18:421P.</div>  <br>  <div align="left">14) Michel, R.N. and <span style="font-weight:800">Boudreau, C.</span>  1992.  Functional axon sprouting of tetrodotoxin-inactivated rat plantaris motor units after partial denervation of the muscle. <i>Soc. for Neurosci.</i> 18:218.</div>  <br>  <br>  <div align="left"> <u><i><span style="font-weight:800">c) </span></i></u><u><i><span style="font-weight:800">Chapitres et articles de revues</span></i></u> </div>  <br>  <div align="left">1) Jasmin, B.J., <span style="font-weight:800">Boudreau-Larivi&egrave;re, C.</span>, Adatia, F.A., Angus, L., Chan, R.Y.Y., Kotlarewsky, M., Krupa, A.M., and Mankal, F.A. 1998. Molecular mechanisms controlling the synapse-specific expression and activity-linked regulation of acetylcholinesterase in skeletal muscle fibers. In:  <i>Structure and Function of Cholinesterases and Related Proteins</i>, B.P. Doctor et al. (Eds), Plenum Press, New York, p. 45-50.</div>  <br>  <div align="left">2) Jasmin, B.J., Gramolini, A.O., Adatia, F.A., Angus, L., <span style="font-weight:800">Boudreau-Larivi&egrave;re, C.</span>, Chan, R.Y.Y., Krupa, A.M., Lunde, J.A., Mankal, F.A., Wu, J. 1998. Nerve-derived trophic factors and DNA elements controlling expression of genes encoding synaptic proteins in skeletal muscle fibers. <i>Can. J. Appl. Physiol.</i> 23:366-376.</div>  <br>  <div align="left">3) Jasmin, B.J., <span style="font-weight:800">Boudreau-Larivi&egrave;re, C.</span>, Chan, R., Hubatsch, D.A. and Sveistrup, H.  1995.  Neuromuscular factors influencing acetylcholinesterase gene expression in skeletal muscle fibres. In: <i>Enzymes of the Cholinesterase Family.</i> A.S. Balasubramanian, B.P. Doctor, P. Taylor, and D.M. Quinn (Eds), Plenum Publishing Corp., New York, p. 261-267.</div>  <br>  <br>  <div align="left"> <u><i><span style="font-weight:800">d) Autres publications</span></i></u> </div>  <br>  <div align="left">1) Pool, M., <span style="font-weight:800">C. Boudreau-Larivi&egrave;re</span>, Y. De Repentigny and R. Kothary. 2001.  Novel insights into the molecular organization of the dystonia musculorum locus. <i>Canadian Federation of Biological Sciences Annual Meeting.</i> Ottawa, ON.</div>  <br> </span></td> </tr> </table> 				&nbsp; 			</td><td width="40"><img src="/images/dot.gif" width="40"></td> </tr> </table> </td><td bgcolor="#3A7AD1" width="1"><img width="1" src="/images/dot.gif"></td> </tr> </table> </body> </html> 
