<html> <head> <meta http-equiv="Content-Type" content="text/html; charset=iso-8859-1"> <title> propos de la maladie de Pompe</title>  <meta name="Description" content="La maladie de Pompe est une maladie gntique rare, transmise sur le mode autosomique, qui touche environ une personne sur 40000. Elle rsulte d'un dficit en &#945;-glucosidase, une enzyme servant  la dgradation du glycogne, une forme de rserve de glucide qui comble les besoins nergtiques de l'organisme.  dfaut de se dgrader, le glycogne s'accumule dans les cellules, affectant divers tissus, notamment le coeur, les muscles du squelette, le foie et le systme nerveux. Il s'ensuit un ralentissement graduel du dveloppement corporel. "> <meta name="Description" content="La maladie de Pompe peut tre diagnostique durant l'enfance ou l'adolescence ou encore  l'ge adulte. Le pronostic varie suivant l'installation et la gravit des symptmes. La maladie de Pompe se rvle particulirement mortelle chez les nourrissons et les enfants en bas ge. "> <meta name="Description" content="Genzyme Canada s'est donn comme mission d'amliorer la vie des personnes atteintes de la maladie de Pompe en leur offrant son appui au moyen de ressources, d'information et de la recherche."> <meta name="Description" content="Pour obtenir de plus amples renseignements sur les activits de Genzyme Canada relatives  la maladie de Pompe et  d'autres maladies lysosomiales connexes, veuillez composer le (905) 625-0011 ou, sans frais, le 1877220-8918."> <style type="text/css"> <!-- 	.CorpTitle-1 	{ 		margin-top: 15px 	} 	.CorpImage-1 	{ 		margin-top: 15px 	} --> </style> <link rel="stylesheet" href="/css/genzyme_ca.css" /> </head> <body topmargin="0" leftmargin="0" marginheight="0" margintop="0" bgcolor="#FFFFFF"><a name="TopOfPage"> </a>  <!--begin top-->   <script type="text/javascript" language="Javascript"> function openWin(url, properties) { 	window.open(url, "Genzyme" , properties); } function stockPop(which) { 	if (which == "gzbx") { 		url = "http://www.corporate-ir.net/ireye/ir_site.zhtml?ticker=gzbx&script=300"; 	} else if (which == "genz") { 		url =  "http://www.corporate-ir.net/ireye/ir_site.zhtml?ticker=genz&script=300"; 	} else if (which == "gzmo") { 		url = "http://www.corporate-ir.net/ireye/ir_site.zhtml?ticker=gzmo&script=300"; 	} 	window.location = "/home/disclaimer_jumpsite.asp?url=javascript:openWin('" + url + "', 'scrollbars=yes,width=500,height=645,menubar=no,location=no,alwaysRaised=yes')"; }  function sniffBrowser() { 	// sniff off bad browsers 	var bwr = navigator.appName; 	var ver = parseInt(navigator.appVersion, 10); 	var agent = navigator.userAgent.toLowerCase(); 	NS4 = ( bwr == "Netscape" && ver == 4 ) ? 1 : 0; 	NS6 = ( bwr == "Netscape" && ver == 5 ) ? 1 : 0; 	IE4 = ( bwr == "Microsoft Internet Explorer" && ver == 4 ) ? 1 : 0; 	IE5 = ( bwr == "Microsoft Internet Explorer" && ver == 5 ) ? 1 : 0; 	ver4 = (NS4 || IE4 || NS6 || IE5) ? 1 : 0; 	isMac = (navigator.appVersion.indexOf("Mac") != -1) ? 1 : 0; 	iswebTV = (agent.indexOf("webtv") != -1) ? 1 : 0; 	isGoodBrowser = ((NS4 || (IE4 && !isMac) || IE5) && !iswebTV) ? 1 : 0; 	if(!isGoodBrowser) { 		alert("This site is optimized for Internet Explorer 4.0 or Netscape 4.0 or above. 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adhrences</a></td> 			</tr> 			 			<tr> 				<td height="2" colspan="2" background="/images/common/dotted_line.gif"><img src="/images/common/trans.gif" height="2" width="1" /></td> 			</tr> 	 			<tr height="16" valign="top"> 				<td width="12"><img src="/images/icons/icon_gray_square_off.gif" width="12" height="16" /></td> 				<td width="120" class="sectionnav"><a href="/thera/ct/ca_fr_p_tp_thera-heart.asp" target="_top">Chirurgie cardiaque et pulmonaire</a></td> 			</tr> 			 			<tr> 				<td height="2" colspan="2" background="/images/common/dotted_line.gif"><img src="/images/common/trans.gif" height="2" width="1" /></td> 			</tr> 	 			<tr height="16" valign="top"> 				<td width="12"><img src="/images/icons/icon_gray_square_off.gif" width="12" height="16" /></td> 				<td width="120" class="sectionnav"><a href="/thera/joint/ca_fr_p_tp_thera-ortho.asp" target="_top">Arthrose</a></td> 			</tr> 			 			<tr> 				<td height="2" colspan="2" background="/images/common/dotted_line.gif"><img src="/images/common/trans.gif" height="2" width="1" /></td> 			</tr> 	 			<tr height="16" valign="top"> 				<td width="12"><img src="/images/icons/icon_gray_square_off.gif" width="12" height="16" /></td> 				<td width="120" class="sectionnav"><a href="/thera/diag/ca_fr_p_tp_thera-diag.asp" target="_top">Traitements diagnostiques</a></td> 			</tr> 			 			<tr> 				<td height="2" colspan="2" background="/images/common/dotted_line.gif"><img src="/images/common/trans.gif" height="2" width="1" /></td> 			</tr> 	 </table>    <!-- start essence bar -->    </td>  	<td colspan="3" width="589"> 	<img src="   					/images/photos/ca_img_fr_p_tp_thera-pompe.jpg 				 " /></td>  </tr> <tr height="1"> 	<td colspan="3"><img src="/images/common/trans.gif" height="1" width="1" /></td> </tr> <tr valign="top"> 	<td width="379" valign="top"><img src="/images/common/trans.gif" height="1" width="379" border="0" /><br />    <!--end top--><p class="CorpTitle-1"><b><span style="font-family: 'Arial'; font-size: 11pt; color: #669999">&Agrave; propos de la maladie de Pompe</span></b></p><p><a name="P24_284"></a><span style="font-family: 'Arial'; font-size: 8pt; color: #666666">La maladie de Pompe est une maladie g&eacute;n&eacute;tique rare, transmise sur le mode autosomique, qui touche environ une personne sur 40&#160;000. Elle r&eacute;sulte d'un d&eacute;ficit en &#945;-glucosidase, une enzyme servant &agrave; la d&eacute;gradation du glycog&egrave;ne, une forme de r&eacute;serve de glucide qui comble les besoins &eacute;nerg&eacute;tiques de l'organisme. &Agrave; d&eacute;faut de se d&eacute;grader, le glycog&egrave;ne s'accumule dans les cellules, affectant divers tissus, notamment le coeur, les muscles du squelette, le foie et le syst&egrave;me nerveux. Il s'ensuit un ralentissement graduel du d&eacute;veloppement corporel. </span></p><p><a name="P25_828"></a><span style="font-family: 'Arial'; font-size: 8pt; color: #666666">La maladie de Pompe peut &ecirc;tre diagnostiqu&eacute;e durant l'enfance ou l'adolescence ou encore &agrave; l'&acirc;ge adulte. Le pronostic varie suivant l'installation et la gravit&eacute; des sympt&ocirc;mes. La maladie de Pompe se r&eacute;v&egrave;le particuli&egrave;rement mortelle chez les nourrissons et les enfants en bas &acirc;ge. </span></p><p><a name="P26_1107"></a><span style="font-family: 'Arial'; font-size: 8pt; color: #666666">Genzyme Canada s'est donn&eacute; comme mission d'am&eacute;liorer la vie des personnes atteintes de la maladie de Pompe en leur offrant son appui au moyen de ressources, d'information et de la recherche.</span></p><p><a name="P28_1297"></a><span style="font-family: 'Arial'; font-size: 8pt; color: #666666">Pour obtenir de plus amples renseignements sur les activit&eacute;s de Genzyme Canada relatives &agrave; la maladie de Pompe et &agrave; d'autres maladies lysosomiales connexes, veuillez composer le (905) 625-0011 ou, sans frais, le <br> 1&#160;877&#160;220-8918.</span></p><!--begin bottom-->  <br />    	    	</td>    	<td width="4"><img src="/images/common/trans.gif" height="1" width="4" /></td>    	<td width="210" valign="top"><img src="/images/common/trans.gif" height="1" width="210" border="0" />    	    <br />    	  <table border="0" width="219" cellpadding="0" cellspacing="0">  <tr><td colspan="2"><img src="/images/common/trans.gif" height="1" width="219" border="0" /></td></tr>  <tr>  <td height="24" width="15"><img src="/images/common/trans.gif" height="24" width="15" border="0" /></td>  <td width="195" colspan="2"><span style="font-family: 'Arial'; font-weight: bold; font-size: 8pt; color: #669999"><b>RENSEIGNEMENTS :</b></span></td>  </tr>  <tr height="85" valign="top">  <td><img src="/images/common/trans.gif" height="1" width="15" /></td>  <td>  <span style="font-family: 'Arial'; font-size: 8pt; color: #666666"><b>Genzyme Canada</b><br /> Bureau canadien</span><br>  <span style="font-family: 'Arial'; font-size: 8pt; color: #666666">2700 Matheson Blvd. East</span><br>  <span style="font-family: 'Arial'; font-size: 8pt; color: #666666">East Tower, Suite 800</span><br>  <span style="font-family: 'Arial'; font-size: 8pt; color: #666666">Mississauga (Ontario)  L4W 4V9</span><br>  <span style="font-family: 'Arial'; font-size: 8pt; color: #666666">Canada</span><br>  <span style="font-family: 'Arial'; font-size: 8pt; color: #666666">N<sup>o</sup> de t&#233;l.&#160;:&#160;(905)&#160;625-0011</span><br>  <span style="font-family: 'Arial'; font-size: 8pt; color: #666666">N<sup>o</sup> de t&#233;l&#233;c.&#160;: (905)&#160;625-7811</span><br>  <span style="font-family: 'Arial'; font-size: 8pt; color: #666666">N<sup>o</sup> de t&#233;l. sans frais&#160;:&#160;1&#160;877&#160;220-8918</span><br></td>  <td><img src="/images/common/trans.gif" height="1" width="15" /></td>  </tr>  <tr>  <td height="15" colspan="3"><img src="/images/common/trans.gif" height="15" width="1" /></td>  </tr>  </table>    	</td>    </tr>    </table>  	 	<!-- begin footer -->  <! 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