Sequence-structure-function relationship of proteins with repetitive
sequences.

Kajava, A, J

Proteins having arrays of tandem repeats represent at least 14% of all
known proteins. Sequencing projects revealed a big number of proteins
having tandem arrays of 5 to 30 residue long repeats. The known 3D
structures of these proteins have a solenoid-like arrangement. Their
elongated shape and large molecular weight hamper conventional X-ray
and NMR studies, therefore, theoretical deciphering of the
sequence-structure-function relationship of such proteins promises to
be a fertile research subject of structural bioinformatics.

Documents : Article de survey sur le sujet
Kajava, A, J. of Structural Biology 134, 132-144, 2001