Genomic Instability and the Evolution of Cancer

Francesca Ciccarelli, PhD, European Institute of Oncology (IEO) Milan, Italy, http://ciccarelli.group.ifom-ieo-campus.it/fcwiki/

• Abstract
  Cancer is often associated to genomic instability, defined as the
  dynamic acquisition and propagation of genomic modifications. In
  several cases these modifications are causally implicated in the
  initiation and development of the disease. The latest improvements in
  sequencing technologies have boosted the discovery of
  cancer-associated modifications, thus allowing the investigation of
  several aspects of cancer genomic instability. In this talk, our
  contribution to the understanding of the genetic and genomic
  determinants of cancer will be presented. Particular emphasis will be
  laid on the method that we developed for detecting of
  cancer-associated genomic instability using next-gen sequencing.