Protein PVX_080105 (TriTrypDB link) - New domain DUF1777 (Pfam link)

Sequence and domain localizations (colored) at: 1653...1818 

   1 MECVSHDGRSTNGAGCNKELTNSSGNSKSIEMHAYKNKFEKSPNCEQNGQAAIRTSNKKS   60
  61 EERKNHMNYCTDNDQVDNFKVVHTYSGTSQKSRKNGRTKNFSKNKADFNHFFYEEKYANS  120
 121 SYVEKGKRPDRHYPHGGLGSNRGVNDNRLRKGTSSGNCSSGNNNNNNMGVHNPIESFGKN  180
 181 YSGSRMNVANGAEEKVAKRVASNNENLVPTGDKSHLGMVDGRSRRRGANSEKQPFVFANK  240
 241 RGGSGSYNDQNAGTVEYANDDDRVAAEQLGVGGSMCGDICGDMCGDRYSRKGDFPNDGTP  300
 301 PRKKSSFLRKSKSLNRNNIYESKEDDKRMVSITNRDPPENMDYTNVTKKACSNNELKFKE  360
 361 KKKDEANCTSREVNYDFKSALNIQFSKTKMCPYMNTKEKCKRFLSNMCPYAHDQSELKPF  420
 421 PDLYKTAMCRNFMKNLCSKSKIECNFAHNVQELRSTDEFYKTTLCKFFLNGYCKADTNCR  480
 481 HAHGHKELKSKEAKCKEAKRKEVNCEEVNCEGVNGEEVNGEGVNCEEVNGEGVNCGEVNC  540
 541 GEINREGVQHRNLGSLSWEIDRVGTEKANNNEEEEQPQHPQQLHQLRQSDLDGGETLLNG  600
 601 ETMNRFKSSESCSLSEGKEVRIIRGGEDAAEEDLLAEEDIEEDDEVVDVIAVEGKRISNT  660
 661 RDRKKNDSKKNDGKKNDRKKKKEKFYNASRKLMSISTKDTYCFLSNGFSRNMESSENFDD  720
 721 ENRSVRTNEDSTLAHSNGDSKMKSSDSANSYFKGDPHPEYPFKSNETIYRMELKDEEVNH  780
 781 SCDATGREAQNGSDTEQGHHSVDHNEQVNTSRHFGERSHDMADGKQERDHSNRFTHSNSH  840
 841 RGSNVALSGSLALKKEGRKIFNEDSAYAHRNKVSVGGGKGSNEATVHPKMDRNKNGRGYM  900
 901 NPNFAPMGSKGGTRNFQDKMGNGKLSRNVQVDAIEVNDGMGPPSEMHFSGLCENGMNGYD  960
 961 GAVGHTGGCGGRDSNGYGQERGDNYTWENHTKENHAGEHNRGGYRSKGFHNANKGNGDRS 1020
1021 GGGNFHSGGNSNFNGAFGNSADNYGGGVGKQYGNGKRANGGTARYDGHPGSRDSSNSGVA 1080
1081 NRGAANSSVVNSGVVSGGFANNGMMNNNLGNNNLGNNNLGNNNMVNSNMMRNNFRGNHAR 1140
1141 NATRNVRHGARNGLRNGGMANYAANPNGANPNGANPNGANPNSIYPNGANPNSAYHNDVV 1200
1201 ENNMRTMHPEHVNTYNNNFSCYNVRGGDANVYMSMNNFPYKNAPQGSNCNVVGRAPGKID 1260
1261 HSSCGGNYGGSYGGNYGGNYGGNYGGSNGGNYSGNHGGHYGNVGSGPVGGNNHPYPPQDY 1320
1321 APPICNSAMKQSKNYRGKKKSGQNNMPYEMRNNGNFENSSGYDRNVNMYSRGGVKRDGNY 1380
1381 NAHGFNPSGTIGSMNNDHHVDGNIYGDMFMNNGPRNNQQDGVNNIYGSGNGNNYYPYGYD 1440
1441 TSGTHVMNAPLENGADVRNEGMEPSVHGGHMYNATRAYGFADGQSAAHDGTQNGSHHGAN 1500
1501 NAVPNGSHHGTHHGTHHGAHHGAHHGANNGVQNDTHRAFRQMDKKAHSGNIDPMHGGRNR 1560
1561 KGHMSNSAYNETYKSGEENCSHAVSRADGANIASAANLGHPFACDPGVHDETSLEGGSFL 1620
1621 SRKPRGCPSNSLKSGHMAEGAELKRNNYDETNIGTKKSDHIGKSERENRKEGRSGDQSAG 1680
1681 EMKGTAYCPSFSANDNTNKAEQSTQLKENNRGNSKECSTRRNRNGSKNGENNDGGIMRDM 1740
1741 HGSTNRSTLRTLAECISPVNGAADQPPLCGDGQMESSTIEKMKQKNYDSTGEHVKSSNLK 1800
1801 SKSPRRRGSRNRRAQHGEHQSRAEHIIKEQHRGEKNQEELHTELQTADHQSKSGILKKDN 1860
1861 KIENVLIDEEPQTCVSCYQYMTDPTPGEITPANPCCLACGQVIKKSLSLMIIELLQPQVQ 1920
1921 HLLSDVNFYVQNYHD 1935

Alignement of domain consensus (first line) on the sequence (colored line).

Each position reports the amino acid with highest probability; capital letters mean highly conserved residues (i.e. with probability > 50%).

Occurence 1653...1818 
   1 MGRSRSrdrdRsprrsRRRgRsRdRdyreyr.rnyeRsRSReDRarrRsRsRsphRSrRs   59
1653 IGTKKSDHIGKSERENRKEGRSGDQSAGEMKgTAYCPSFSANDNTNKAEQSTQLKENNRG 1712

  61 RSPrRvvehernw..qpekkdgRrSrSpsRrrdRkrerekdarFePegdalekvkeikee  119
1713 NSKECSTRRNRNGskNGENNDGGIMRDMHGSTNRSTLRTLAECISPVNGAADQPPLCGDG 1772

 121 dLeGkadeeMKPsgFDTTGKKVdGnDVnvqkKRRkGGFNRPLDFna  166
1773 QMESSTIEKMKQKNYDSTGEHVKSSNLKSKSPRRRGSRNRRAQHGE 1818