Protein PVX_098050 (PlasmoDB link) - New domain PI3Ka (Pfam link)

Sequence and domain localizations (colored) at: 318...517 

   1 MDHKTDGKEDHKREGKTEGETGQTGKEDAGDTTEGADQREKWTAAPEESTSYRSLYKHNY   60
  61 KAHVYADDFVCLRLKGRGGEGHDDGSSEPQQCVEPFEGDLPVGGCPHDDTPVGELSTKRD  120
 121 NNEEVAATGRDNLCGVAVDRIDEANPPREDAQYVQVGSRMEDHQPDEAIYSQAGTQHSNH  180
 181 ANEEKRENSDLQPHSDDNYTLQESYSSDCHLKEEMPHESNQPSEDLPSWEAHKMKEKDQP  240
 241 PEKQNKIKIIEMFKMKLESKEMNRSRHFGDDVRGGGPGGAHHDGYGDGRDDGRDDGRDDG  300
 301 HDDGHGDGHDHSGGASPGASNRCTQIRESISRIFSESPSSKPKIISELKHGEGHPNSGSN  360
 361 GSGSHHSSGTHHGSGSNGSGSHERERADGKANGAKNALKEGSLLRLFRCEYFDTHLHIRY  420
 421 LYDRREVGVHEYLVNSLYTQRKYEDILFYLPQLSQISLVRYESSSLYRFLLCKASNSMHF  480
 481 ALKLSWIYHSIVEDNSSKYKDLAHKMTQEIEMAVVNCKPFNGKGTSGNENKQSYLLNLAH  540
 541 PLLFKRKYLIKRIKDNERFERTKLSRNCLNRSCNLCLLKGGEESTQSGMEVAVQGETQRN  600
 601 SQSADLSSAPNAAPSAAPNAAAHAATHAAAHASPKKRRKREATSTAPPPKLPQCYIVNSG  660
 661 ALSIARARVKLPSTYAKLGNPLSASKFFLPEFNCTFDMIGELQQFFMKQRRCDYFSLLNN  720
 721 FVNLTISVSNLLSTEPDVEIRNELLNRFIYSLNSWMLMRRCIVAACTNVFSMTGLCIPLE  780
 781 CLSPPQSGQRTEPTPSSNGSNSNGSSNISGSSGSSGSGLQILHFNYDECKIFFSKKRAPY  840
 841 LLMFEVADLDEDISHIPDGLFYPSSVGGDEAAGEEEEEAGQTASETAGEAADGATRGVTD  900
 901 EPTSQPTPPPRRKGHRIERNFCSSKNYGLFNENSSSYDYEPRGGVHDGKRKKKKKKKKRR  960
 961 SESGEDDEGGAHTGQSGSEVDRGKEERGKGAQGKKTTGADLDALKMEHMYVYNCIVNDLR 1020
1021 KENLISFPSGEEDSLSIIRKCIGMRADEEDEEGGDTEGGDTNGGDPGDPSEPSNLGQGGP 1080
1081 GWGAPPAEEGPREATKSFLVNARSASMPNYLSSSLERCNISSNDNDSNEVKTSVESISSG 1140
1141 LADLPPGGLHGSEVDAQVDAQEDAQVEAPDGGWSPSPGKRPNDSGVTADQPLEGAAPSPH 1200
1201 SSFLHAGEKTGDALDIDEYFKPANYTNEEFKKRYCRVIKRLLWGELFEEKKKKIRKTSAY 1260
1261 GKLKTWDLKCVIVKGGDDLRQELLASQLIRQFKIIFENAGLPLWLRPYEILVTGANSGII 1320
1321 EYVNDTCSVDSLKRKFGADSISTIFNVVFADYIFEAKKNFIESHAAYSLVSYLLQVKDRH 1380
1381 NGNLLLDSDGHLIHIDYGFMLTNSPGNVNFETSPFKLTQEYLDIMDGEKSENYEYFRRLI 1440
1441 VSGFLEARKHSEEIILFVELMMPALKIPCFANGTQFCIDSLKERFMTNLAVDVCIQRINA 1500
1501 LIESSINNFRSVQYDYFQRITNGIM 1525

Alignement of domain consensus (first line) on the sequence (colored line).

Each position reports the amino acid with highest probability; capital letters mean highly conserved residues (i.e. with probability > 50%).

Occurence 318...517 
  1 kdlkpnekerkeleaIlayDPlsnPkALKlLlSVkWsdlsevaealsLldk.........  59
318 GASNRCTQIRESISRIFSESPSSKPKIISELKHGEGHPNSGSNGSGSHHSSgthhgsgsn 377

 61 ...............Wap..idpvdALELLdpkFadkteeVR...........eYAVkcL 119
378 gsgshereradgkanGAKnaLKEGSLLRLFRCEYFDTHLHIRylydrrevgvhEYLVNSL 437

121 esasDeE.LlfYLLQLVQA..LKYEdSpLsrFLlqRAlkNrrlGHfFfWyLksEikdvse 179
438 YTQRKYEdILFYLPQLSQIslVRYESSSLYRFLLCKASNSMHFALKLSWIYHSIVEDNSS 497

181 rFgvllEsylrecsleglnk 200
498 KYKDLAHKMTQEIEMAVVNC 517