Protein PVX_098660 (TriTrypDB link) - New domain Toxin_R_bind_N (Pfam link)

Sequence and domain localizations (colored) at: 1802...1989 

   1 MGVKLALLMSLLLIRGGTEIGVLVSKLSGGKNGRLLLNVTNHKCEKCKKGFYNFSRDNKI   60
  61 CLPCPLGTFTHAEGSIVCTNCPGGSTTKSTGSESSRACVCSKGFKVDTTDGRCAKCSALE  120
 121 SCDDGENVWSFKNMCTKERGEEYVELCRNVRTDQVYSFQISCFKKDVCLNHKEGKTCLEG  180
 181 NKLIQCKICDENFRYDFVTPVKRPCVLCSFTTYVVSLYFIALGFFLSLLIFTCVGRERES  240
 241 EMKIIRLVVKYTQFMSLLRYVNSNYSHFLLDALHFFTVGVPLNEVLDCIFARGTNGERIE  300
 301 KKVDFLLFLPLLFLVFSLFGTIALRLLRRNNKSKAEESGKYFAQLFILYHEYLYLEIIRL  360
 361 CVFFYFCNYDEERRGDFLIVDDSLECKKMRTKYFVKIWIIVLYNTLVNYFDYFLFFLKKY  420
 421 IPRLDALCVLKAKVSTLSPPDDIFLLLFLFFFHKRFFSNVKASLTVNHKNGIYNNNVHTF  480
 481 QFVVIAVSFSLYTLVTFLCVYRCDDCAGGVVLEELEKRRNVGHIVGASPVYEEEEGTKRE  540
 541 AKKKEVAREKSDNNEGEAEEVELKSGEMGVPHGEAREKGEEEEKEAGEDAGEEEHKRGTP  600
 601 SGGDKQGHPATPSCFIQVVNLLSKLVKKRRTEKFFFYFSMFVHVTISLSYYTFLSYVHAR  660
 661 QFLGVLTTISVLCNGLIYATIFLLLIKLGKGNNLKKGNKKWFRISSIRRRIGKAKWVAIW  720
 721 RRRKASGTEKEQTNSKHVVIFQNRNNKMEEKYHLKNEKRSIILINNILKNSKSFQVHFGE  780
 781 VARKSESDSSVKNGESNKFIRRYKLLNISKKWVTFLQNVVGLSDEPEKCLSMLISLTLEE  840
 841 EFPSLDLDACLEVVKKNYFAPMENVTTILKNFLKYTNKFLAILGRRRKGEKKTSNGGGSK  900
 901 CTFGRLTDCDESAIVFAWGLGILSFGNLQDVNYNLSPVLFHVSNVLAKCRYMKYIIDYYF  960
 961 RYMPYWGILPFGGLGNYYLPCETTTGGALPICDSINNLYVCQEGESNFNGGGPGGVDNQT 1020
1021 VVSEALGEDRHTDVYINGKREHLNVDAANQQACLGPRFTRTGKMESYSGELAISLSGCTH 1080
1081 RRKTQSGLSNRRRGTPGRRDNQAGDGLPLEFDFNRIYAKELCRIYIHCLLADVSEIYKGI 1140
1141 HYTQTCEKYLCSGVLNLWGEHHKSRSNMYMRRYYEHLERWAGLEENNAGGASSRGEVKQG 1200
1201 GMDPTEAFFNIEDYISSRVIEIDFYGQFEHLKRDTKDYLMSLVKEGDALHVKELTNFSEV 1260
1261 PRDRLHEMERKEKEEKEKEKKRKRKNEQFCKVFCSALPVCIEKRCWEFLDKSELKQIEEE 1320
1321 KRQRRNFTISCENMGEEYFNAHVLKNYEEKVTYFRIDCYGGVISVGGEFVNRKGEFPRVG 1380
1381 KKEKGRKKTATDGDKKGETNFTEEKDDNFLTEEGVHILNTNMHNYVNYERVEGSKMEIFT 1440
1441 HNSYEGDVGITGDLKGMNFRDRNALVVLTPPVVIPKECTIEVWLFIGSREGATNGWEKSF 1500
1501 LFCDVEGNSPFVISRRGNKIEDIEIHISDKRRLSSYFRQLHSEGRREPMDGEKATEKGNH 1560
1561 WSVYIKCEKTPKWNKINSIVKQNQWNLLNITKCASGLIYYLNGKYMNSVSHEVLNLEKQF 1620
1621 QMSVFGNSCFGNNNIGLCSSFKIFEFLKKEEIKRRYEIVKKVKGREMVGDNLCMEIKDQV 1680
1681 IEGIDVRDKCMQVLEFFMYFAQSQRGKTRVVAFTNDSNYRVRMYQLRLGSKYTRGTAPGG 1740
1741 GGGPGESGPVKNPPSAHFHERNGEELHSKGNKLGLTNLPNGEEEGRENLHRRCEKIIHID 1800
1801 DKEEYGYNVYFKKVSRREDAPKIYGINIFSDLLCYACDLSKFYNLILDPPLSLYNELVKP 1860
1861 FGYTLCLWVFLPIEENVSFSSLVSGEKDAHISVFSDRLLIGCVENYKRGKKQGQTFYHSS 1920
1921 GFSVKNVKRGWYYLTVVGTLKGQFYFINGCFKGHHNFCSFDDVKYVGNSSLFINPFPYIC 1980
1981 FFKMVTKPLSVTEIMCEYACPAYDKLAVSPGSSYWYLLFANLFGRTAPNDGSVDSLSDKS 2040
2041 TSSTGSDKGRYVHFEITDFFDVHVYPYRERKYYPFALSVTSMENRKLFLFNKKKEQINNL 2100
2101 TVHLNVSIVLPSCWAIFAVINLAYVNKSAYHCLVGGQNGDSHVAIKGSNLALGVLTHLGE 2160
2161 DFLQKGEIPDEVTTGERANHLARGSSSNDKKEAASRGTKEMGNTAHSQTDSNMCYQNYQH 2220
2221 FHSSGYHLQKELNEEILLTTICRKNEQTFFINSHEVGVSKSCLSPICCIGNCRSVSGEFL 2280
2281 SPFGFYKFVRVVFGDVTDEQVAQFHRSLPC 2310

Alignement of domain consensus (first line) on the sequence (colored line).

Each position reports the amino acid with highest probability; capital letters mean highly conserved residues (i.e. with probability > 50%).

Occurence 1802...1989 
   1 nNvlGYna...lVeygddvqLvyGInknqfkLksseeiVsqnndi......fyNslynNF   59
1802 KEEYGYNVyfkKVSRREDAPKIYGINIFSDLLCYACDLSKFYNLIldpplsLYNELVKPF 1861

  61 ..SIsFWlRipKynnnneYtIInsmknNkIslegNglLiDsngneks.....iyFeYsis  119
1862 gyTLCLWVFLPIEENVSFSSLVSGEKDAHISVFSDRLLIGCVENYKRgkkqgQTFYHSSG 1921

 121 ndiSdyiNkWfFvTINdRLgnqkIYINGkLianesIknLgnI.yssnnIsfvdeyiwIey  179
1922 FSVKNVKRGWYYLTVVGTLKGQFYFINGCFKGHHNFCSFDDVkYVGNSSLFINPFPYICF 1981

 181 FsIFnkeL  188
1982 FKMVTKPL 1989