Africa France Bioinformatics

PCV: Laboratoire de Physiologie Cellulaire Végétale

The Éric Maréchal team (Chemogénomique comparative des plantes et des parasites apicomplexes) is developing a project to create a African collaborative space on bioinformatics and chemogenomics on the malaira agent, within the framework of the actions supported by the NEPAD.

Main Activities:

Chemogenomics.
Molecular phylogeny.
Phylogeny-based target discovery.
Drug discovery.

Recent Publications:

Bastien O., Ortet P., Roy S. & Maréchal E. (2007)
The configuration space of homologous proteins: a theoretical and practical framework to reduce the diversity of the protein sequence space after massive all-by-all sequence comparisons.
Future Generation Comput. Syst. 23:410-427.

Birkholtz L.-M., Bastien O., Wells G., Grando D., Joubert F., Kasam V., Zimmermann M., Ortet P., Jacq N., Saidani N., Roy S., Hofmann-Apitius M., Breton V., Louw A.I., Maréchal E. (2006)
Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space.
Malaria Journal 5:110.

Bastien O., Ortet P., Roy S. & Maréchal E. (2005b)
A configuration space of homologous proteins conserving mutual information and allo-wing a phylogeny inference based on pair-wise Z-score probabilities.
BMC Bioinformatics 10;6(1):49.

Bastien O., Roy S. & Maréchal E. (2005a)
Construction of non-symmetric substitution matrices derived from proteomes with biased amino acid distributions.
C. R. Biol. 328(5):445-53.

Bastien O., Lespinats S., Roy S., Mé K., Fertil B., Codani J.J. et Maréchal E. (2004b)
Analysis of the compositional biases in Plasmodium falciparum genome and proteome using Arabidopsis thaliana as a reference.
Gene 336:163-173.

Bastien O., Aude J.C., Roy S., Maréchal E. (2004a)
Fundamentals of massive automatic pairwise alignments of protein sequences: theoretical significance of Z-value statistics.
Bioinformatics 20:534-537.

Contact:

Eric Maréchal
UMR 5168 CNRS-CEA-INRA-Université J. Fourier
Département Réponse et Dynamique Cellulaires - Laboratoire PCV
17 Rue des Martyrs
38054 Grenoble cedex 9 FRANCE
E-mail: emarechal@cea.fr
Tel: 33 (0) 4 38 78 49 85
Fax: 33 (0) 4 38 78 50 91

Mailing list Bioinformatics in Africa report This report was written by Alia Benkahla, Winston Hide and several african researchers. Most of them were invited at JOBIM 2005 thanks to the CNRS - MAE bioinformatics program, and belong to the ASBCB.

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