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GEM : Gene Expression Modelling

Project Leaders : Dr. Eric Rivals (LIRMM), Dr. John Palmeri (L2C)

NUMEV labs involved : LIRMM, L2C, IMAG

Partners: IGF (Institut de Génomique Fonctionnelle), IGMM (Institut de Genétique Moleculaire de Montpellier), IBC (Institut of Computational Biology of Montpellier)

The way a cell controls how genes are activated to produce RNA and proteins relies on a complex process called gene expression. It involves several levels of control, the two major ones being the transcription from DNA into RNA and the translation from RNA into proteins. Gene expression is a key to understanding cell differentiation and plays an important role in diseases like cancer. This project aims at investigating the mechanisms and dynamics of transcription regulation and translation.To address such complex issues, we will combine the modeling capacity of biophysics with the genome wide analyses of bioinformatics to investigate major questions regarding the control of gene expression. The aim of this project will be to launch a new type of multidisciplinary collaboration in synergy between biology, biophysics and bioinformatics. The final objective is to establish in Montpellier a dynamic community focused on modern genomics applied to the medical sciences, and to develop multidisciplinary training programs at the University of Montpellier.