sequence comparison

Hardness of optimal spaced seed design

Speeding up approximate pattern matching is a line of research in stringology since the 80s. Practically fast approaches belong to the class of filtration algorithms, in which text regions dissimilar to the pattern are first excluded, and the …

Longest common subsequence problem for unoriented and cyclic strings

Given a finite set of strings X, the Longest Common Subsequence problem (LCS) consists in finding a subsequence common to all strings in X that is of maximal length. LCS is a central problem in stringology and finds broad applications in text …

Comparison of Minisatellites

In the class of repeated sequences that occur in DNA, minisatellites have been found polymorphic and became useful tools in genetic mapping and forensic studies. They consist of a heterogeneous tandem array of a short repeat unit. The slightly …

Transformation distances: a family of dissimilarity measures based on movements of segments

MOTIVATION: Evolution acts in several ways on DNA: either by mutating a base, or by inserting, deleting or copying a segment of the sequence (Ruddle, 1997; Russell, 1994; Li and Grauer, 1991). Classical alignment methods deal with point mutations …