Glad to announce a new publication of a collaborative work, with 7 distinct research teams in biology, bioinformatics, and medicine: 5 from the area of Montpellier, one from Curie Institute in Paris, and one from CHU of Rennes. The project was led by Prof. Jerôme Moreaux from CHU Montpellier and focuses on the results of Laure Dutrieux during her PhD.
This work deals with an interesting molecular phenomenon: when two molecular processes acting on DNA, namely the transcription of genes into RNA and the replication of DNA, take place at the same time on the same genomic region. This might results in conflicts. Many fundamental questions a the center of this research project: Where do such conflicts occur? Which sequence patterns may favor such conflicts? How do they impact gene expression regulation?
But also practical questions: how can the resolution of such conflicts impact cancer treatments in the case of Multiple Myeloma, a deadly cancer of the bone marrow.
Check it out in a freely accessible article https://doi.org/10.1016/j.bneo.2025.100072
Elle Loughran contributed to the bioinformatic data analysis during her PhD visit to our lab, at the LIRMM Montpellier during summer 2023.
Congrats Laure, congrats Jérôme, and congrats to all authors.