Happy to share our new preprint available on BioRxiv. This research investigates the capacity of cancer cells to become resistant to one of the most utilized cancer therapeutic drug, fluorouracil, a.k.a. 5-fluorouracil or the 5-FU for short. We investigated how cancer cell lines react over several days, during and after treatment, in terms of major molecular processes such as RNA transcription and RNA translation.
Our results show that this acquired tolerance is controled through a deep change in RNA translation, which impacts other molecular aspects of cells life that underly the acquisition of resistance.
This collaborative endeavor is the outcome of a cancer research project led by J.J. Diaz from CRCL in Lyon, one of our collaborator in this domain. Thanks for all participants.
Check it out on the related publication page
Translational control of cell plasticity drives 5-FU tolerance bioRxiv 2024.07.03.601826; doi: https://doi.org/10.1101/2024.07.03.601826
QR Code for preprint doi:10.1101/2024.07.03.601826
Translational control of cell plasticity drives 5-FU tolerance on BioRxiv
Collaborators involved: A. David, J. Ripoll, C. Mandier